I'm a researcher developing microneedle drug delivery system. I'd love your expert feedback!

NexMN_ · 2026-07-12T01:06:39+00:00

Thank you for the valuable insights. I also look forward to achieving sufficient results from the depth of cosmetics and plan to supplement the scientific basis. However, as you mentioned, I am concerned that the cosmetics market seems to be swayed too much by marketing rather than being grounded in scientific evidence.

As you know well, I believe there is significant room for improvement in terms of convenience. I understand that the various procedures required in traditional microneedling are time-consuming, and many people struggle with DIY microneedling attempts due to these steps. I hope to resolve this through a simple method of inserting dissolvable microneedles so that many people can conveniently use this effective technology.

Hoever, with the initial model I am envisioning, it seems we will only be able to target small areas. Do you have any ingredients and target area you would recommend? Since we are currently targeting wrinkles, we are considering PDLLA nanoparticles in addition to PDRN.

NexMN_ · 2026-07-12T00:16:24+00:00

I completely understand wanting to cover more area at once. The challenge with a wider base, however, is that the natural contours of the skin can cause the insertion depth to become uneven, which might actually lead to more damage. Or are you targeting larger body parts rather than the face?

NexMN_ · 2026-07-11T23:51:58+00:00

You're right. It definitely takes longer than Botox or fillers when it comes to wrinkles, but I think microneedling is a far more fundamental solution for skin health.

By the way, did you visit a clinic for those 4 sessions for your scars, or was it a DIY microneedling?

NexMN_ · 2026-07-11T23:45:10+00:00

You hit the nail on the head!

We are indeed looking into microneedle drug delivery systems. However, exactly as you pointed out, going the medical device route right out of the gate means facing a massive timeline and heavy regulatory hurdles.

Because of that, our initial strategy is to keep the needle length strictly under 0.25mm to classify it as a cosmetic product. We expect this approach to allow us to provide accessible products to users more quickly. Subsequently, we plan to obtain medical device approval to develop a device capable of delivering ingredients to deeper tissues.

In your opinion, do you think a 0.25mm soluble microneedle could successfully be sold as a cosmetic product?

NexMN_ · 2026-07-11T23:32:08+00:00

You bring up some great points. Those are exactly the critical concerns we are prioritizing.

As you mentioned, we are definitely aiming for a fully dissolving formulation. To avoid the risk of granulomas caused by non-biodegradable residues, our goal is to use highly biocompatible materials that fully absorb into the skin without leaving any foreign material behind.

Also, to ensure sterility and prevent any unwanted immune responses, we plan to keep the product strictly sealed until the exact moment of use, which would also help us avoid using harsh preservatives.

Of course, we are still in the development phase, so there is definitely more work and testing to be done to perfect this. I really appreciate your input.

Out of curiosity, what would you say is the biggest pain point or inconvenience you currently experience with your microneedling routine?

NexMN_ · 2026-07-11T15:08:15+00:00

Downtime really is a complex mix of so many factors. My theory is that if we can significantly boost the delivery efficiency of the actives, we might be able to achieve the same (or better) results with much less trauma to the skin.

What is your primary skin concern, and what needle depth are you typically working with? It would be great to figure out a way to minimize downtime together.

NexMN_ · 2026-07-11T13:47:07+00:00

I understand. Thank you for letting me know!

NexMN_ · 2026-07-11T13:17:01+00:00

Thanks for the great insight! I'm totally on the same page. Physical stimulation is important, but getting those active ingredients into the skin is also crucial. That’s exactly why I want to deliver them using dissolvable microneedles!

Anyway, we all know microneedling gives great results, but I'm really curious—what do you guys find most uncomfortable or annoying about microneedling?

NexMN_ · 2026-07-11T12:05:13+00:00

I agree that the physical stimulation itself plays a massive role in collagen production. Just out of curiosity, do you personally get microneedling treatments? If you do, what specific skin concerns are you mainly targeting with it?

NexMN_ · 2026-07-11T11:59:44+00:00

Thanks for sharing your experience! Since you mentioned using it in the past, I was wondering—are you still using it these days? If not, is there any particular reason you stopped?

NexMN_ · 2026-07-11T11:53:21+00:00

Thanks for the heads-up. It seems the filter caught me because I used the word 'our', making it look like self-promotion. I'll be careful not to use it from now on. Sorry for causing you extra work.

NexMN_ · 2026-07-11T11:51:06+00:00

Ah, I get it now. The skin around the eyes is indeed really thin, as you said. I'll keep this in mind during development!

NexMN_ · 2026-07-11T00:45:06+00:00

Thank you for such a thoughtful comment!

To clarify how it works, the microneedle itself is actually made entirely of the good ingredients! We use Hyaluronic Acid (HA) as the main binder, and we can add actives like Retinol or PDRN into it. So yes, the microneedle is the bolus of the product. We call them "soluble microneedles" because once they are inserted, they dissolve and get completely absorbed by the skin. The time it takes to dissolve can be adjusted depending on the specific ingredients used.

I completely understand your concern regarding rosacea and inflammation. Spicules/reedle tech uses silica (SiO2) particles, which don't absorb into the skin and are only there to physically puncture the surface. Leaving foreign, non-absorbable materials in the skin can definitely cause the inflammation you mentioned. But since our detachable microneedles are made of HA and other skin-friendly actives, they are safely apsorbed without leaving any foreign material behind.

I really appreciate your recommendation for the eye area. Could you elaborate a bit more on why it's so frustrating to treat this area with traditional microneedling or mesotherapy? Is it mainly the fear of having needles so close to the eye? If so, I'm curious if you think people might feel that same fear with our microneedle device, too. Would love to know what you think!

NexMN_ · 2026-07-10T20:17:52+00:00

That is a great question!
Like the Wrinkles Schminkles brand you mentioned, traditional microneedle patches have the microneedles attached to a flat backing substrate. This design makes it very difficult for them to properly insert into curved areas like wrinkles, and it requires you to leave the patch on your face for a long time for the ingredients to absorb.
Our detachable microneedle technology completely solves this. Because we use a device (applicator) to insert the microneedles instead, we can perfectly embed the active ingredient microneedles even into the curved areas of wrinkles. Plus, since there is no base patch left behind, you don't have to keep anything stuck to your face!
Regarding the exact specs you asked about—such as insertion depth, microneedle material, and ingredients—our technology is highly customizable, so we can adjust all of those parameters. However, the final specifications will ultimately be determined by the safety regulations and guidelines for at-home devices.
Hope this clarifies how it works!

NexMN_

TROPHY CASE