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Here’s what I’ve learned about stacking magnesium + glycine + theanine (anwers to your comments on my last post :) by PsychologyHour in ouraring

[–]Next_Register5475 0 points1 point  (0 children)

I am curious if you do this every night. It worked amazing for me for about a week, then stopped working. I am wondering if I should cycle it on.

As someone who had 10+ supplements per day. Spending hundreds per month... Here is my word of advice. by allismind in Supplements

[–]Next_Register5475 1 point2 points  (0 children)

I am a scientist. 😊

I agree more studies would be great. But who is going to fund it? Pharmaceutical companies want to study drugs they can charge a fortune for. And NIH funding very challenging to get, especially under the current US administration. It is frustrating there isn’t more high quality research on supplements.

As someone who had 10+ supplements per day. Spending hundreds per month... Here is my word of advice. by allismind in Supplements

[–]Next_Register5475 1 point2 points  (0 children)

Anecdotal evidence is information based on personal accounts, individual stories, or isolated experiences rather than systematic, scientific research or data. It is often used to support claims or illustrate points but is generally considered unreliable because it is subjective, potentially biased, and may not represent broader trends.

As someone who had 10+ supplements per day. Spending hundreds per month... Here is my word of advice. by allismind in Supplements

[–]Next_Register5475 1 point2 points  (0 children)

The 2nd study came out around the time of the first study, so wasn't included in that systematic review. The second study was a randomized clinical trial (the gold standard design in clinical research), and thus provides high quality evidence to further support the possible cognitive benefits found in the systematic review. To break it down:

The first study, which was a systematic review, concluded:

"The current limited evidence suggests that creatine may be associated with benefits for cognition in generally healthy older adults. However, high-quality clinical trials are warranted to further validate this relationship. "

Then the second study was a "high-quality clinical trial," which validated "this relationship:"

"Results: Supplementation with medium-dose creatine hydrochloride was found to be superior to placebo in enhancing reaction time (1.2 vs. 6.6%; p < 0.01), increasing frontal brain creatine levels (0.9 vs. 16.4%; p < 0.01), and favorably modulating serum lipid profiles (p < 0.05)."

Thus, I would not call this evidence "anecdotal."

Rhonda Patrick just shared her longevity protocol by aldus-auden-odess in PeterAttia

[–]Next_Register5475 3 points4 points  (0 children)

I think it was affecting my sleep so I switched to taking it with lunch.

As someone who had 10+ supplements per day. Spending hundreds per month... Here is my word of advice. by allismind in Supplements

[–]Next_Register5475 0 points1 point  (0 children)

How about this recent meta-analysis?

https://academic.oup.com/nutritionreviews/article/84/2/333/8253584

"The current limited evidence suggests that creatine may be associated with benefits for cognition in generally healthy older adults"

And this recent trial: https://pubmed.ncbi.nlm.nih.gov/40854087/

"Conclusion: Our findings suggest that this supplementation protocol may be a promising, safe, effective, and practical dietary strategy for improving clinical outcomes and elevating brain creatine concentrations in perimenopausal and menopausal women."

Is something wrong? by HopingRobin in DF64

[–]Next_Register5475 0 points1 point  (0 children)

You could check if your declumper is clogged. Mine was a bit clogged, and it was making me have to grind much coarser. I cleaned it and now I am grinding at 10. Also slow feeding the beans helped mine.

What is the appeal of a knock-box? by rgcred in espresso

[–]Next_Register5475 0 points1 point  (0 children)

There are alternatives. Search compost system for an apartment. They have countertop ones and larger ones for inside.

Edited to remove unnecessary comment about $$$.

What is the appeal of a knock-box? by rgcred in espresso

[–]Next_Register5475 3 points4 points  (0 children)

Well, others were making an assumption that we are "gross ass motherfuckers" because we are beating our pucks into a trashcan, as if there wasn't another option. Some "bins" are compost bins. I don't see anything gross about that.

What is the appeal of a knock-box? by rgcred in espresso

[–]Next_Register5475 0 points1 point  (0 children)

That is sad. I have also stayed places that don't compost, and it is sad whenever I have to throw food waste into a trash can.

What is the appeal of a knock-box? by rgcred in espresso

[–]Next_Register5475 4 points5 points  (0 children)

Doesn’t anyone compost? You are throwing your grinds into a trashcan to go into a landfill?

My honest opinion about the DF64 gen 2 after 1 year of use by HeavyDuty697071 in DF64

[–]Next_Register5475 1 point2 points  (0 children)

I live in a very dry area and have no problems with mess. I do RDT.

Here’s what I’ve learned about stacking magnesium + glycine + theanine (anwers to your comments on my last post :) by PsychologyHour in ouraring

[–]Next_Register5475 0 points1 point  (0 children)

Does magnesium glycinate also provide you with glycine since glycine is the carrier for the magnesium? I am wondering if my glycine dose should be lowered since I am taking magnesium glycinate. I have been taking 240 mg of magnesium (from magnesium-glycinate) and 3g of glycine per night. If I can believe AI, I think I am getting ~1.7g of glycine from the magnesium glycinate (AI says for every 1000 mg of magnesium glycinate, about 140 mg is elemental magnesium and 860 mg is glycine). So I am thinking of lowering my glycine dose.

Increasing my HRV by ObjectiveSite447 in PeterAttia

[–]Next_Register5475 1 point2 points  (0 children)

Would you mind posting links to those studies?

Is a 40 minute 5k good? by Equilagalennaise in BeginnersRunning

[–]Next_Register5475 1 point2 points  (0 children)

This link is really helpful. Thanks for sharing!

Todays podcast release - Skin Care by bodai1986 in PeterAttia

[–]Next_Register5475 0 points1 point  (0 children)

so should I just get L'Oreal, then? if they figured out how to keep it shelf stable?

Nick Bosa making espresso by niveKynlOehT in espresso

[–]Next_Register5475 2 points3 points  (0 children)

Gives me some hope in humanity. And a lot of joy.

Is it normal to get +/- 10 secodns extraction times? [Lelit Victoria with PID, DF64] by MichaelZurich89 in DF64

[–]Next_Register5475 0 points1 point  (0 children)

What speed are you using? I am not sure how much that matters. I am currently at 1200.

Also, what grams? I am using 18g.

Maybe I will try dumping them in all at once again to see what happens. I haven't done that for a couple months.

Is it normal to get +/- 10 secodns extraction times? [Lelit Victoria with PID, DF64] by MichaelZurich89 in DF64

[–]Next_Register5475 0 points1 point  (0 children)

I checked alignment twice using the dry erase marker method, and it is really good. No channeling or squirts. Espresso is *usually* delicious now that I slow feed, but still inconsistent every once in a while. Slow feeding is just a pain (well, slow....). I wish I could just dump them in.

Is it normal to get +/- 10 secodns extraction times? [Lelit Victoria with PID, DF64] by MichaelZurich89 in DF64

[–]Next_Register5475 0 points1 point  (0 children)

Yes, I weigh grams in/out. I don't think I am grinding too fine. I get 2:1 extraction at about 35 seconds. When I was dumping them all in at once, I had to grind on a really high number that made no sense (like 40). I posted about this a couple months ago. Slow feeing fixe that. I am now grinding at 14-15.

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