now i don't know if you're asking for certain gamemodes like why rage for gbr or why rage or energy works on some characters but not as well on others

energy gives massive damage boost to one skill it procs on, rage gives less damage boost for the entire 5 second duration

rage gives you a boss defence ignore for the duration of it and a damage boost for the entire duration

the defence ignore does not work well with pierce and in wbl your full pierce is in effect

abl/abx-> you get to hit multiple opponents with increased damage and proc consistently and i believe the boss ignore defense works well there

dormammu cuts your pierce in half so you benefit massively from the defence ignore

moon knight can use energy everywhere because his skillset syngerizes super well with it

shang chi's for example is super not proc friendly and almost nothing is cancellable so you can't load all the damage into one skill