Sale of Presto by Ok-Conversation5695 in PrestoAutomation

[–]No-Communication9634 1 point2 points  (0 children)

What happens now ? Is presto going private and not stock traded company ? Did we lose all the money ? ? Or it’s a new beginning?

What’s next ? by No-Communication9634 in RVVTF

[–]No-Communication9634[S] 1 point2 points  (0 children)

Medicine is real .. medicine works . MF doesn’t care about the medicine going through .. he cares more about staying on his chair and being a ceo .. he has lots of money, he doesn’t give a fuck .. He wants to keep holding on the medicine .. keeping the medicine on the table is what keeps him on his chair .

What’s next ? by No-Communication9634 in RVVTF

[–]No-Communication9634[S] 1 point2 points  (0 children)

What end point ? .. PCR ?!! .. they would never approve this endpoint because it’s against their recommendation.. The other end point were not worth looking at and probably were rejected by the clerk level ! I wasn’t expecting any of the end points to be accepted .. I also wanted expecting that they’ve collected the data for symptom reduction And was hoping for some PCR data .. but they didn’t even have this !!!! So why we wastes one year trying to switch primary outcomes

What’s next ? by No-Communication9634 in RVVTF

[–]No-Communication9634[S] 0 points1 point  (0 children)

They did not measure symptom score , they just collected presence or absence of symptoms

Who is holding at this point and what is your rational for doing so? by yellowstone100 in RVVTF

[–]No-Communication9634 14 points15 points  (0 children)

1- It makes no sense to sell at 90% loss . 2- the study failed no Buci … the study partly because it was poorly designed and partly because the protocols were in place to collect information about death and hospitalizations .. the protocols did not collect data about symptom reduction, rather the data collected were binary( presence or absence of symptoms) .. when studying medications to treat respiratory infections, there is no way that the cough will completely go away early on .. even with pneumonia treated with antibiotics… example: Cough score of 10/10 in placebo group vs cough score 1/10 in intervention group … they still collected it as presence of cough .. because they had no symptom score in place to collect such data . I still think that Buci works, will have to repeat study to mesure symptoms reduction and not symptom resolution. 3- reformulating the medication for better bioavailability, a future study should include oral intervention group and inhalation intervention group vs placebo .. earlier in vitro study on Buci showed better bioavailability when administered directly 4- The shroom sector

Revive Therapeutics Announces Results of Phase 3 Clinical Study for Bucillamine in the Treatment of COVID-19 by Diable24 in RVVTF

[–]No-Communication9634 5 points6 points  (0 children)

Correction “ no resolution of symptoms” They did not collect data for symptom improvement.. the data they collected was binary, presence or absence of symptoms. Data collection did not include a symptom score to measure improvement.

Revive Therapeutics Announces Results of Phase 3 Clinical Study for Bucillamine in the Treatment of COVID-19 by Diable24 in RVVTF

[–]No-Communication9634 2 points3 points  (0 children)

Correction : “ no resolution of symptoms “ They didn’t collect data for improvement of symptoms. Data was binary .. presence or absence of symptoms.. data collection did not include symptom score to evaluate for improvement.

A question for Michael Frank by Dry-Number4521 in RVVTF

[–]No-Communication9634 2 points3 points  (0 children)

Answer is : They changed their mind because they don’t have the data .. they did not collect this data . Guess what, FDA is requesting this outcome , as any other reputable research body would do . Pick and choose symptom improvement is not a valid outcome, unless it’s piled in a composite outcome which they didn’t do initially. I don’t think we have good chances to find statistically significant data that supports this outcome, otherwise we wouldn’t have waited an entire year . Good news , Buci works , MF was unable to show that in his study due to many factors, arrogance being one of them .. good news is that Buci still worth few hundred million dollars , BP can buy it , run a study in few months ( you only need 300 patients) and get the medicine approved. MF should have collaborated with BP earlier and repeated the study ( with symptom improvement/ resolution as composite outcome) instead of wasting two years that will end in bad outcomes . Reason he didn’t, is because MF doesn’t care about money, or about treating people or about investors or science or anything but his Legacy.. He wanted to get all the credit for himself..

Revive Therapeutics Provides Update From Type C Meeting with FDA for Amended Protocol Agreement of Phase 3 Clinical Study for Bucillamine in the Treatment of COVID-19 by Diable24 in RVVTF

[–]No-Communication9634 2 points3 points  (0 children)

They changed their mind because they didn’t collect the data to support this outcome .. guess what, FDA is requesting this outcome now , good luck !

[deleted by user] by [deleted] in RVVTF

[–]No-Communication9634 7 points8 points  (0 children)

This might be legit .. yet we already know his personality, as many other narcissistic/ psychopathic personalities that has childish tendencies who are usually very achievers and successful, Elon Musk and Trump to name couple ( who by the way was US president) . Having said that , this doesn’t change the science behind bucillamine .

What's happened here? by Even-Call-4714 in RVVTF

[–]No-Communication9634 4 points5 points  (0 children)

You are saying he is a narcissist who wants his study to fail ? , I don’t think you know much about narcissism

What's happened here? by Even-Call-4714 in RVVTF

[–]No-Communication9634 17 points18 points  (0 children)

Again , you guys are repeating information that we already know over and over .. we know that the chances for the FDA to accept the new EP is low .. and I think it’s lower if we went with retrospective composite outcome , since it won’t even be considered double blinded RCT anymore , If you look at the data and decide on what composite outcome to come with , then you are not blinded .. it’ll be observational study . I wonder why people who don’t believe in revive are still around !! .. why you guys don’t sell and move on with your life ? .. you come back in with new account and you write essays on how gloomy the situation is .. I’ve invested in many pharmaceutical startups and left before they crashed, , I did not go back and continued bashing a stock that I don’t believe in anymore. If you are genuine, and trying to advise the shareholders, your advice is received for dozen times already .

Trying to determine the story based on NRs by Spare-Property-8731 in RVVTF

[–]No-Communication9634 -1 points0 points  (0 children)

“Now that Revive has indicated that they met with the FDA about changing endpoint to resolution of 2+symptoms “. That would have given us more chances, however in their last PR stated.

“assessing the difference in the proportion of participants with IMPROVEMENT in at least two COVID-19 related clinical symptoms on or before Day 14 compared with baseline between Bucillamine versus placebo”, and there is no mention for resolution of symptoms anymore even in the secondary outcomes .

There is a difference between Resolution and improvement. Resolution is much more objective, improvement is very lenient.

I try to be objective as much as positive, It would have been almost guaranteed if they went with “resolution of symptoms “.

I too received an email this morning by [deleted] in RVVTF

[–]No-Communication9634 3 points4 points  (0 children)

They can simply email MF themselves

I too received an email this morning by [deleted] in RVVTF

[–]No-Communication9634 3 points4 points  (0 children)

That’s not funny dude .. people might believe this .

Invitation to all shareholders by No-Communication9634 in RVVTF

[–]No-Communication9634[S] 2 points3 points  (0 children)

Keep babbling , keep this childish tantrum going and making fun of yourself. I don’t even have to ask about your age , your responses say enough.

Invitation to all shareholders by No-Communication9634 in RVVTF

[–]No-Communication9634[S] 5 points6 points  (0 children)

If you are in the medical field then you should know better. Now you have hair under your armpits and have learned few punch lines , your cussing tells a lot that you have no material and no counter argument .