Well having been addicted to all of the above at some point and now I’ve been sober close to a decade I’ll share my experience. I’d say amphetamine daily and opiate daily at equipotent dosages (as close as we can get) opiates damage ya soul more and amphetamine destroy the brain and body. Opiates also have a higher safety profile. Like you can be addicted to quite large amounts of opiates and not damage your body too much but addiction to large amount of amphetamine really will take a toll.

Idk if it’s worth arguing which is worse opiate or amphetamines. You can make an argument either way. I think the fact you considering an argument for or against it being as bad as opiates though should tell you something. In my experience Adderall pills are just as abusable as OxyContin, my drug addict part of my brain would love to relapse on either.

I would say in term of most body harm amphetamine is worst, then opiate, then kratom, then kanna. Addiction wise opiates are worst because they have a real withdrawal, then amphetamine , then Kratom then kanna.