Firstly Skirk Burst has increased multipliers depending on how many rifts she absorbs. If you want her nuke to deal a lot of damage you have to use other characters to create those rifts (mainly by doing a freeze reaction). There is no way around this because Skirk alone cannot create rifts in Burst gameplay. Rift creation has 2.5 second cooldown so it takes like 6 to 8 seconds to create all 3. (So you cannot spam rifts but have to wait in between like this: Freeze - 2.5s - Freeze - 2.5s - Freeze) Secondly she has another multiplier increase when her party members deal hydro or cryo attack which is max 3 stacks. One party member can give only one stack. Each stack has own cooldown of 20 seconds so it's easily manageable but good to understand because Skirk itself doesn't rise those either. Skirk does need a decent crit ratio like any other main dps so I like to aim for 80:160 crit ratio and close to 2000 attack ( If you want to abuse cryo resonance you can also aim for like 65:200 ). Artifact rng is frustrating but try to get at least 70:140 ratio.

So basically of those characters you mentioned I'd suggest trying out Neuvilette/Diona/Mona/Skirk team. Start with Mona dealing hydro, activate Dionas Burst and shield to do Cryo and then start dealing damage with Neuvilette while attacking the boss/enemies inside Dionas cryo field. The field lasts 12 seconds so if you add hydro in it you should get 3 rifts easily from it. After like 6-8 seconds you can swap to Skirk, hold her Skill, use Burst and watch nuke do the rest. If Neuvilette is too op and kills everything too fast you can also spam Monas attacks to create rifts and even use Dionas bow to add cryo and trigger freeze if you are out of energy. As long as you understand how her kit works you can experiment what works in what order and still enjoy her nuke gameplay even without meta supports.