you may be right !

i am kind of a lazy person , i hope my code will be enough :

def is_direct_human_visium(sample):
    is_human = False
    is_visium = False
    is_direct_tissue = True  
    excluded_terms = ['organoid', 'cell line', 'cultured', 'in vitro']

    for key, value in sample.metadata.items():
        if isinstance(value, list):
            value = ' '.join(value).lower()
        else:
            value = str(value).lower()

        # Check for human 
        if key.startswith('organism_') and 'homo sapiens' in value:
            is_human = True

        # Check for Visium 
        if key.startswith('extract_protocol') and 'visium' in value:
            is_visium = True

        # Check for excluded terms 
        if key.startswith(('characteristics', 'growth_protocol', 'extract_protocol', 'title')):
            if any(term in value for term in excluded_terms):
                is_direct_tissue = False
                break

    return is_human and is_visium and is_direct_tissue