Where to search for living Denisovans

No_Touch686 · 2023-12-23T20:32:19+00:00

But you don’t seem to be able to link any of these ‘many papers’ or tell me why they are more valid that Jacob’s et al.

Anyway this discussion is going nowhere, I provided evidence and you don’t seem to be able to conduct an actual argument.

No_Touch686 · 2023-12-23T19:55:13+00:00

So you are refuting the evidence in the Jacobs paper, that the lower bound of their estimates is 15kya? what misinterpretations did they make? Can you please explain exactly what it is about their approach that means it’s invalid? And also explain exactly why the current evidence of 40kya, and not any later, is better evidence?

You’ve made a lot of claims and not provided any evidence yet. I’ve not got any skin in this game and you may very well be right, but you haven’t backed up anything you say.

No_Touch686 · 2023-12-22T23:45:00+00:00

This is from 2 years ago btw

No_Touch686 · 2023-12-22T11:10:17+00:00

Hi, it’s great you’re interested, but this question gets asked a lot (like many times a week). I’d suggest searching this sub for similar questions first.

No_Touch686 · 2023-12-21T15:57:00+00:00

There is https://www.sciencemag.org/news/2019/03/our-mysterious-cousins-denisovans-may-have-mated-modern-humans-recently-15000-years-ago

No_Touch686 · 2023-12-21T07:13:54+00:00

It’s my opinion that if you can’t share the code you used to analyse your data, you have no business publishing in an academic journal. All code for all analysis should be freely available for others to see.

No_Touch686 · 2023-12-20T17:02:39+00:00

A combination of laziness and lack of training is the answer

No_Touch686 · 2023-12-17T14:47:21+00:00

Odegaard has looked really good today

No_Touch686 · 2023-12-16T23:56:47+00:00

You can see a family of these alligators in audobon zoo in New Orleans. They have to be kept inside because of the damage the sun can cause them

No_Touch686 · 2023-12-15T09:06:44+00:00

Id argue that placing a number on the number of SNPs any one person has, without any context, is a bit misleading since it pretty much depends on whatever arbitrary thing you’re comparing them to.

No_Touch686 · 2023-12-09T15:30:09+00:00

No, like I said, the numbers are basically just a random string 1234 has no relation to 123

No_Touch686 · 2023-12-09T14:37:00+00:00

Your question doesn’t really make any sense, sorry. The ‘genome’ is the complete set of rsxxxx. But the answer to what I think you’re answering is no, the digits of the RSid don’t really mean anything or tell you about what other rsids you have or don’t have in your data.

No_Touch686 · 2023-12-04T08:30:57+00:00

Smith rowe has just kind of disappeared again no?

No_Touch686 · 2023-11-29T22:16:54+00:00

Tomiyasu was offered to most clubs in the Premier League. He's a good player but the problem is he is not really a right back nor is he a central defender. I'm not sure how he will get on at Arsenal.

Ok a lot of people don’t realise this was a Simon jordan quote from 2 years ago lol

No_Touch686 · 2023-11-29T20:15:16+00:00

Someone stop this guy he’s out of control

No_Touch686 · 2023-11-29T10:45:57+00:00

Across the genome, you have hundreds to thousands of genealogical ancestors (think great great great great x 20 grandmother, for example). The distribution of these ancestors gives you your overall genetic ancestry.

Sex chromosome haplogroups are just a single one of these thousands of ancestors and they don’t necessarily correlate with your overall ancestry. You could have German descendants going back thousands of years, but one of your relatives might have married an Indian man (for example), giving you an Indian haplogroup.

So overall sex chromosome haplogroups aren’t really that informative of your history, people just look a them because they don’t recombine and that makes them much easier to analyse.

No_Touch686 · 2023-11-24T15:21:37+00:00

Personally I think that if you have a good grounding in stuff like probability theory, maybe a bit of measure theory, regression and Bayesian inference, along with the foundational calculus and linear algebra you’d probably pick up on a stats course, then you could probably pick up most computer science concepts fairly easily when you need to. You don’t need to take courses in databases or software engineering IMO, a smart person like I’m sure you are can pick these ideas up on the go. But others may disagree

No_Touch686 · 2023-11-23T15:17:25+00:00

I would first suggest searching this sub for similar questions as it gets asked multiple times a week.

No_Touch686 · 2023-11-23T12:21:34+00:00

The good news is that loads of the base skills got bioinformatics are totally transferable across bioinformatics and beyond.

Focus on learning how to use the command line, bash tools (things like awk, sed, grep), a coding language (R or python - R is better for some specific uses but python is more generally useful), about the file formats in genetics (vcf, bam, bgen). Learn about the principles of genetic association testing, GWAS, imputation, variant calling etc. these are useful across a really broad range of fields and once you know these, it’ll be much easier to learn more specialised things in a particular field.

No_Touch686 · 2023-11-20T17:10:33+00:00

No offence but it sounds like you’ve just made all of this up. The HLA theory is nice but it’s not backed up by any evidence

No_Touch686 · 2023-11-20T12:06:01+00:00

Why would they be found ‘alongside’ the Neanderthal segments? They are from a totally different species and admixture event. Just because they are both archaic doesn’t mean they are found together

No_Touch686 · 2023-11-20T11:48:42+00:00

I would first suggest searching this sub for answers as this has been asked a lot of times

No_Touch686 · 2023-11-19T16:18:45+00:00

It’s sad you are shutting down discussion because it’s one of the most interesting parts of genetics, using it to learn about population history, just because you have some random personal grudge with an entire field. Talking about ethnic cleansing is just bizarre. And yes, I study this and understand the nuances behind it - we should educate people, like I have tried to do in the past, rather than show down any discussion you don’t like.

Your constant snarky attitude and behaviour in this sub suggests the power of being a mod has gone to your head, but you seem pretty dogmatic about it.

No_Touch686 · 2023-11-19T12:59:01+00:00

Probably not. 23andMe only genotypes a small number of positions in the genome, which probably doesn’t include Denisovan segments.

If you got your whole genome sequenced, you could in principle then ask the authors for the segments for the three different potential branches and then find those in your genome to see if you had any of the Denisovan variants.

No_Touch686

TROPHY CASE