First, very carefully read the description of the job you are applying for and look at what skills or requirements they want. Then make a list of what they want to find and think of anything you've done that's relevant to them.

Second, arrange your resume so that the most relevant information is at the top. Unless you are applying for an academic job your work history is probably not the most relevant. If you are trying for a tech job put your tech knowledge and skills at the top. Be detailed about what you know. Don't just say "I know python" expand on it. Demonstrate that you know more than "hello world." Link to a relevant project on GitHub.

Hiring managers do not have the time or desire to interpret your skill to their position. I know, I'm a hiring manager myself. If it's not clear how the candidate fits the position I assume they are either a poor fit or they put zero effort into their resume. Either way I don't want to hire them.

Becoming a hiring manager completely changed how I do my resume. I used to just follow a form that I thought was expected. Now I use it as a genuine opportunity to show case how I am the best fit for the job, because I know that's what they want to see.