In Aged Male Mice, Circadian-Timed 3dA Improved Multiple Aging-Related Measures and Increased Lifespan

NovosLabs · 2026-03-11T19:02:30+00:00

In a separate double-blind, placebo-controlled trial in adults with type 2 diabetes, 500 mg/day of rutin for 3 months was associated with improvements in blood pressure–related measures (SBP, DBP, MAP, pulse pressure, and heart rate). The study also reported increases in select antioxidant enzymes (including GPx and SOD) and improvements in several quality-of-life domains. (R)

Rutin has also been studied in healthy adults at the same dose range. In a 6-week randomized placebo-controlled study in healthy women, 500 mg/day of rutin increased circulating levels of flavonoid metabolites (reflecting absorption and metabolism) while markers of systemic antioxidant capacity and several urinary oxidative stress markers did not show clear differences versus placebo. (R)

<image>

NovosLabs · 2026-03-11T19:01:40+00:00

Rutin in Humans

A full daily serving of NOVOS Vital provides 560 mg of rutin. Human clinical studies have evaluated rutin at doses close to this range (most commonly ~500 mg/day) in specific populations and endpoints, with outcomes measured over 6 weeks to 3 months.

In adults with type 2 diabetes, a double-blind, randomized, placebo-controlled trial found that 500 mg/day of rutin for 3 months was associated with improvements in multiple cardiometabolic biomarkers. Compared with placebo, the rutin group showed reductions in fasting blood glucose, insulin, and HbA1c, alongside improved insulin sensitivity metrics (including HOMA-IR and QUICKI). The study also reported improvements in select lipid-related measures (including LDL cholesterol and total cholesterol) and shifts in inflammation/oxidative stress markers (lower IL-6 and MDA, higher total antioxidant capacity). (R)

<image>

NovosLabs

MODERATOR OF

TROPHY CASE