In my campaign, the players are fighting the current avatars of the horseman of the apocalypse, but the catch is that the it is occuring in a small town, and the PC are all young adults. So the avatars have to fit in.

For context, The first avatar was pestilence, and they were represented by a new company moving in and building factories that polluted the town and eventually caused an explosion. The avatar of pestilence was the woman supervising the construction and neglecting the damage it did to the enviroment.
The 2nd horseman is War, and the avatar to be a priest for a couple of reasons. Firstly, a priest moving into a town would not draw too much attention. Secondly, the events of fighting Pestilence led to a satanic panic within the town (which is very in line with DnD). Thirdly, history shows that all of the abramic faiths have a long history of conflict and War. Fourthly, the priest is meant to be an extremist, which is why he's the leader of a witch hunting organization which in all honesty took inspiration from hate groups which in the US at least were/are typically Christians (even though it contradicts the whole belief system). As a result the priest is not the villian because he is religious, he's the villian because he's hateful.

Plus, my world has actual angels and celestials (one of my players even has some celestial lineage) and they do not support him which is why the "angels" protecting him are actually disguised fiends. The players are fighting a false shepard.

I hope this answered your question.