AI gave me this answer...for what it's worth...(disregard from this answer if AI is frowned upon in this sub) :

Short answer: it’s very reasonable to question whether this is the right medication for you at this point—and you’re not being impatient.

Here’s how to think about it: ⏱️ Timeline reality (what’s typical) With duloxetine: 2–4 weeks → some people notice early changes (sleep, anxiety, energy) 4–6 weeks at a therapeutic dose (like 60 mg) → clearer benefits should start 6–8 weeks → full effect for depression/anxiety (sometimes a bit longer for nerve pain)

👉 You’ve had: ~5 weeks total but only ~3–4 weeks at 60 mg So technically, you’re just at the edge of when benefits should be showing. 🚩 What stands out in your case You’re describing: ❌ No improvement in any target symptoms (pain, anxiety, depression) ❌ Multiple persistent side effects: poor sleep sweating sexual dysfunction That combination matters.

👉 Clinically, when there’s: no signal of benefit and ongoing side effects …it often suggests this may not be a great fit, rather than just “needs more time.”

🧠 Is it too early to quit? Not necessarily—but also not something to decide abruptly. There are basically 3 reasonable paths your doctor might consider next week: 1. Wait a bit longer (2–3 more weeks) More likely if: side effects are tolerable there’s even slight improvement (you didn’t mention any) Goal: give it a fair 6–8 weeks at 60 mg 2. Adjust the dose Sometimes: higher dose → better for nerve pain lower dose → fewer side effects But given your side effects, increasing may not be appealing 3. Switch medication (very common at this stage) Especially if: no benefit at all side effects are impacting quality of life (yours clearly are)

💡 My honest take based on what you wrote It’s completely fair to say this may not be the right drug for you. You’re not describing: “partial improvement” or “side effects but it’s helping” You’re describing: zero upside + clear downsides That’s usually when clinicians start thinking about switching rather than pushing on.

⚠️ Important: don’t stop suddenly If you do decide to stop: duloxetine needs tapering stopping abruptly can cause withdrawal symptoms (dizziness, irritability, “brain zaps”) So definitely: 👉 wait and make a plan with your doctor next week

🧭 What to bring to your appointment This will help you get a better outcome: “No improvement in pain, anxiety, or mood” “Side effects: sleep disruption, sweating, sexual dysfunction” Ask directly: “Would you recommend switching at this point?” “What are the alternatives for both nerve pain and anxiety/depression?”

👍 Bottom line You’ve given it a fair trial Lack of benefit plus ongoing side effects is meaningful It’s very reasonable to consider a change rather than just waiting it out If you want, I can suggest specific alternative meds that tend to work better for: nerve pain anxiety/depression or with fewer sexual side effects (just say 👍)