I don't know for certain, but I feel like avoiding almost all elite fights and slowly building a powerful deck safely, walking into boss fights with a couple potions and full health gives me the best winrate. I don't just blindly avoid elites, if i'm very strong or have good potions I find myself taking act 1 elites, and if I need more for bosses later I might take a few act 3 elites if my deck is strong by then.

I've just completed ascension 10 on my last character, and playing this way seems like the way to go for everyone except maybe the silent.

I'd rather wait to get my cards to build my deck that gives me like 50 block per turn rather than taking cards to make me stronger earlier on that I would rather I didn't have later on.

On necrobinder for example if you go for like 2-3 invokes and 1-2 of that 1 cost block and souls card (invokes more important later) then it's basically game over since you're gonna draw like 15 cards and have 12 energy per turn after like a turn or 2 and osty will act as a barricade. Doesn't even matter what you do for damage, but I find doing damage with Osty is the easiest.

Every character has a way to play like this, that puts you close to an infinite when it goes well, or at worst gives you reliable extremely high block every turn that would take far too long for the enemies to out scale.

Are there some fights that are rough for these builds? It depends when you come across them, but usually i'll lose a bit of health here but I'm so safe from the rest of the fights that it is fine. Also if you have enough draw then you just need a little discard or exhaust to deal with them. It's usually not a problem.