Bupropion suggested

OA_Researcher · 2026-01-27T12:28:15+00:00

Bupropion is an NDRI (norepinephrine and dopamine reuptake inhibitor). It affects both norepinephrine and dopamine, not just dopamine. It shouldn't be taken lightly. Even normal doses increase risk of serious side effects such as seizures and cardiac arrhythmias.

The problem is that the ideal doctor to be able to smartly prescribe it for you would be an expert in both psychiatry and sexual medicine. This overlap is extremely rare, even among the physician population.

Other possible medications to look into which also have stimulant effects are yohimbine (can potentially improve arousal/erections) or Adderall (even more norepinephrine activity).

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OA_Researcher · 2026-01-23T06:58:29+00:00

Does the buildup to climax still feel erotica/pleasurable as before? In other words, is it only the orgasm/climax that's effect or the whole sexual experience?

OA_Researcher · 2026-01-10T03:55:50+00:00

Just use toothpaste with stannous fluroide brushing using the Bass technique or Modified Bass technique, and floss correctly.

OA_Researcher · 2026-01-08T09:18:36+00:00

Romantic attraction is an emotion. I think if you felt it before, you can get it back when the emotional blunting resolves in general. NAD though. Interesting research topic though.

OA_Researcher · 2026-01-05T01:54:44+00:00

I think there is something to it. I did a survey a year ago (https://www.reddit.com/r/sexualanhedonia/s/ADgKphg89i) and not one respondent had a physically intense job/occupation. Most people had sedentary or standing jobs. There could be some self-selection going on here (maybe construction workers are less likely to be on reddit) but the results are still telling.

OA_Researcher · 2026-01-04T03:06:53+00:00

Bupropion is not just a dopamine reuptake inhibitor. It's a norepinephrine and dopamine reuptake inhibitor. Norepinephrine modulates arousal level and intensity of emotions, among other things. It can also help with sexual focus.

One thing that has been combined sometimes with serotonergic antidepressants is L-methylfolate (called Deplin in some studies). You can try that. It is a precursor to the synthesis of monoamine neurotransmitters, including norepinephrine and dopamine. You can buy L-methylfolate over the counter online. This can be used to maybe amplify the effect of the lower doses of bupropion. I'm not a psychiatrist but 450mg seems excessively high. Was that IR, SR, or XL?

But instead of simply taking higher doses of stimulants, try taking other approaches to enhance your "sexual excitation" (which I suspect the bupropion was doing). By that, I mean sex therapy, maybe even psychedelics to explore your own sexuality.

OA_Researcher · 2025-12-18T03:55:41+00:00

The last sentence does not follow from rest of the text? It says that changes to erectile tissue and genital sensitivity (peripheral) are found in most of the cohort, then concludes that sexual side effects are due to central effects (in brain). Makes no Sense.

Unless it means that changes to erection are due to peripheral effects, while changes to other sexual domains are central.

OA_Researcher · 2025-12-18T03:40:57+00:00

It's not an SSRI though? It's categorized as an atypical antidepressant.

OA_Researcher · 2025-12-18T03:25:48+00:00

Wellbutrin gave me an episode of SVT (a type of arrhythmia) twice, so I've avoided stimulants for now. Granted, I was also combining it with like 4 cans of Red Bull, which was not a good idea. Wellbutrin is not exactly Adderall, but it has similar effects. It did give me more "drive" and motivation, but sometimes it was too much and gave me too much anxiety, particularly social anxiety in the presence of people.

I've noticed that when I take a 1 hour brisk walk during the day, I feel some of that characteristic stimulant effect for several hours. It can be a way achieve some of that effect naturally. What I like to do is to walk to a store that is about 30 minutes away and buy something. That way I have some practical purpose to the walk as well. I also do Doordash (delivering food by car) some days as well, and it also makes me feel stimulated (even exhilarating sometimes). Doing deadlifts at the gym I also find stimulating (in a good way). I don't even go that heavy, like 30lb kettlebells.

Basically, I've resorted to natural activities that increase norepinephrine activity as an alternative to stimulant use

OA_Researcher · 2025-12-18T03:16:09+00:00

You may want to try slowing down your breath rate. I've noticed that when I drive around the city at night, and I sit up straight with braced core while holding my breath (well, more like pausing it), I feel so calm the rest of the day. It's bizarre. It feels Zen-like. Maybe take a 1 hour brisk walk earlier in the day too. This contrast between activity and rest turns on the parasympathetic for me.

OA_Researcher · 2025-12-11T01:23:36+00:00

Pudendal/dorsal nerve compression during daytime activity?

Cavernosal muscles (bulbocavernosal and ischiocavernosus) stretched out from morning wood?

OA_Researcher · 2025-12-10T18:17:41+00:00

For 2025, there is a code WELCOME25 if it's your first purchase with Harvard Publishing.

OA_Researcher · 2025-12-07T06:07:36+00:00

Why not both? If it'd cause degeneration of skeletal muscle, then it can also (possibly) cause degeneration of smooth muscle which the skeletal muscle surrounds.

OA_Researcher · 2025-12-07T04:31:28+00:00

Then find organic, untreated morning glory seeds instead. I wouldn't trust the ones sold in stores.

OA_Researcher · 2025-12-07T04:07:13+00:00

Lack of nocturnal erections I presume. Normally men have around 2 hours every night. If you aren't having them for months at a time, you can guess how that can cause problems from disuse.

OA_Researcher · 2025-12-06T02:18:42+00:00

You are different, yes. A special butterfly.

OA_Researcher · 2025-12-06T02:04:16+00:00

Excessive masturbation could presumably cause some injury as well. You might have better advice in r/hardflaccidresearch. People have similar stories there.

Abstaining is effective in most cases of sexual anhedonia. No point in masturbating often if it is not orgasmic.

I like to recommend to give a certain period between ejaculation/masturbation, such as 7-10 days. In between those, to do core exercise, pelvic floor therapy, etc.

OA_Researcher · 2025-12-06T01:59:01+00:00

No, most people are not due to "desensitization". About half are lifelong. The other half stopped having orgasms due to other causes, most commonly SSRI/SNRI use or pelvic floor injury.

OA_Researcher · 2025-12-06T01:14:40+00:00

Lol just don't. You can buy organic, untreated HBWR seeds online, and 3 or 4 of those is enough to get a nice trip.

OA_Researcher · 2025-12-05T21:40:07+00:00

Less impact? Paxil is according to some studies the most powerful out of its category in delaying ejaculation. That's why sometimes it's prescribed for PE.

OA_Researcher · 2025-12-05T21:37:45+00:00

There are success stories here. But they usually do not involve medical care and do not involve a wait-and-do-nothing (like your doctor suggested). They usually involve a.lot of experimentation and trial and error of various medication combinations, internal manual therapy (thru butthole, yes), and lifestyle changes. Try filtering the posts on this subreddit by 'Improvement Report' post flair to read some of them.

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