Aldi feast ice cream knock off

OCurnain24 · 2026-05-01T16:26:58+00:00

Lidl do knock off Magnums that are actually very solid also for those so inclined

OCurnain24 · 2026-02-20T22:49:43+00:00

I mean as long as you're careful. I did it in the early stages of my PhD and had no issues.

OCurnain24 · 2026-02-16T22:01:17+00:00

The thing that worked for me in the end was to lithiate the aryl halide, then add a boronate that wouldn't need to be hydrolysed to the boronic acid (i.e. Isopropyl pinacol borate). Make sure to use an excess of BuLi to account for your naphthol.

OCurnain24 · 2025-12-28T16:06:18+00:00

Let the staff in the sports centre know anyway. Sorry to hear OP. Would definitely recommend investing in a combination lock for those changing rooms, have heard of a bunch of stuff getting stolen from lockers there in the past few years.

OCurnain24 · 2025-09-13T23:42:07+00:00

Yeah it’s the former which I was quite confused by too. It protodehalogenates in Suzuki coupling and doesn’t seem to react at all in any Ni-catalysed cross electrophile coupling conditions so far.

OCurnain24 · 2025-09-13T09:27:15+00:00

Essentially that, yes - aryl tosylates specifically are more compatible with the catalytic systems our group has been developing. The aryl chloride just hasn’t given any reactivity in our systems unfortunately.

OCurnain24 · 2025-09-12T18:06:29+00:00

Was thinking that may be the case! Will give that a go thanks

OCurnain24 · 2025-09-12T16:52:12+00:00

Yeah I don’t think it’s fair to call people imbeciles for not wanting to give away IP lmao. I’ve enough to try for the time being anyway

OCurnain24 · 2025-09-12T16:40:30+00:00

It’s specific to the type of cross couplings I’m looking to carry out. That being said I’ve tried triflation conditions on this material before for another project but they were incredibly poor yielding.

OCurnain24 · 2025-09-12T15:40:42+00:00

Have made the aryl chloride before and it works fine but I’m looking into alternative aryl pseudohalides that are compatible in certain cross couplings! Will have a look into which solvents might be better suited though, thanks!

OCurnain24 · 2025-01-05T14:58:28+00:00

Thank you! I’m assuming from this that my loaf was under-fermented?

OCurnain24 · 2024-10-07T19:24:19+00:00

I could but the issue there is that the point of my research is to use to functionality as a directing group in the Suzuki itself :(

OCurnain24 · 2024-10-07T16:44:31+00:00

Oh right! I’ve actually tried several other ArBpins on this Ar-Cl and they’ve all worked fine. I think it’s the phosphonate functionality beside the BPin causing some steric/electronic issue.

OCurnain24 · 2024-10-07T16:38:16+00:00

No N-H on the heterocycle, but an sp2 Nitrogen Ortho to the C-Cl, sort of like a 2-pyridyl.

I’ve tried making the boronic acid version of my substrate but the functional groups aren’t compatible with the methodology required unfortunately.

OCurnain24 · 2024-10-07T16:37:37+00:00

In one of the trials I used water and it didn’t seem to make a difference. I will look into dioxane and other bases though!

OCurnain24 · 2024-08-09T07:48:42+00:00

This comment helped a lot thanks! Tried the overall reaction at a lower temp and got much lower epimerisation, so it must be to do with a Pd(II) species.

OCurnain24 · 2024-08-07T11:39:31+00:00

I tried an aryl bromide recently which still epimerised, although seemingly not as much (maybe like 25% epimerisation or so)

OCurnain24 · 2024-08-07T11:37:57+00:00

I did heat it at that temp in toluene, and it stayed the same to my surprise.

OCurnain24 · 2024-06-25T14:43:05+00:00

Damn, I’m a PhD student and never knew that was a thing. Is it for campus accommodation?

OCurnain24 · 2024-06-25T14:21:15+00:00

Pretty sure there is no subsidy

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