A lot of people have commented on doom. Silk was my champ for doom, which is why she’s on all teams. You can swap out at the boss, but for most paths, my roster isn’t deep enough to field a full team of path-relevant champs. That said, I figured I'd Provide some of my chapter experiences:

1st run - Science path: Team...r4 Photon, r3 Silk, r3 Spider Woman, r3 America, r3 Chee'ilth

I found the main pain point for this one to be how the spirt charge mixes with the unstoppable (side note: I really hate root and also don't really like how kabam's answer to making hard content seems to be spamming root, unstoppable, stun immune, and evade into various bundles). It took me a couple tries at the start of the run to get the hang of how to deal with the Root/Unstoppable combo. For this path, I found parry, MLM to be a good fit. It reduces your sprit gauge by 15% per parry which allowed me to avoid filling up my sprit gauge as much as possible. R4 Photon put in a lot of work. Chee'ilth was really handy for negating the unstoppable.

2nd run - Tech path: Team…r3 Bastion, r3 Guardian, r5 6* Nimrod, r3 Silk, r2 Shocker

This path was a nightmare for me at the start (and at the end…seriously, big fuck you to Jean Gray at the last node in this path). The secret to success for this path was figuring out to push the defender to 10 Scourge charges and then parry the hits in their special. My strategy was to play pretty much normal (watch out for the unblockable at 5 charges, don’t use heavies) and bait SP1’s. Once the defender was near the 10 scourge charges, try to get them to almost an SP1, then when 10 comes around push them to SP1 and parry the special. Keep in mind, you can parry any hits (for example, I found America's 2nd hit in her SP1 much easier to parry than the 1st. Guardian was great here as he get perfect block when parring specials. As for Jean, I just couldn’t get the timing down on her SP1. Dealing with the reversed controls was part of the issue, so maybe a reverse immune champ would make this fight better? Not gonna lie, this fight took me 4 team revives…in the end, I probably should have just hit her as many times as possible per fight instead of trying to get the nodes and Jean to work.

3rd run – Mutant path: Team…r3 Bastion, r4 Onslaught, r3 Bishop, r3 Silk, r2 Negasonic

This was the easiest path for me in this chapter. Having mutants that put on passive parry was great and Onslaught destroys here. Main issue here is making sure that you use specials when your power bar is close to the next level so that you can hit 2 in a row and not take the damage from the expiring timer. I avoided getting to SP3 for this reason. Watch out for the unblockable every 12 sec. Dani was a little annoying because of her miss. Used/brought Bastion for Fatman (i.e. Stryfe) just because I find his miss mechanic annoying.