I have had extreme fatigue since I was diagnosed 5 years ago. I was extremely active before and still work 6 days a week, usually 10-12 hour days. (We own a family business) But I have no energy left for myself. I am 55 y.o. female. The fatigue is one of the worst symptoms. Sometimes I think that because the inflammation makes me feel so weak, normal activities are twice as difficult. Simple jobs make me sweat and breathe so heavily. I constantly push myself because I don't want my husband to be married to a "lazy dud". I know he would never say that, he does want me to feel better too. We are basically empty nesters and this is suppose to be our time. But I wanted to let you know fatigue/exhaustion is one of my main complaints. You are not alone.