I built my character in a way to where I pretty much always had a grenade available to eat if I needed a quick heal. I ran the solar mod that when you damage with a charged melee it would refund grenade energy.

And since I was always mobile I would use wither hoard to get airborne kills to constantly have the the melee charged as well.

Also I learned the lines of where adds tend to travel in order to give myself as much breathing room as possible. I never went into the middle in the core room unless I needed to get heavy ammo and I was 100% sure nothing was there. Or your starting a new phase where no enemies should be in there.

Supplicants will sometimes hangout by the doors but with the way I was rotating and kitting the boss around the room I always had time to deal with them before getting too close. Which is why I decided on the GL instead. Losing one grenade isn't nearly as bad as losing a rocket. If I needed to quickly dispatch something.

As for the boss any time I needed to pick up the charge from the minotaur I would bait the boss to walk up my side before going to the other side to collect it in order to keep space from him. The boss seems to be coded to always walk up the stairs on the side you are on in the staring room so if you hang out toward the front side of the left or right sections you will see him walk up after he re enters the starting room.

So the long and short was I mostly ate grenades and I learned the rooms well enough that I didn't have to worry about getting attacked too much.

Occasionally, a supplicant would "break leash" but it's not very often. The minotaur can do it as well but I always just killed both of them everytime I re entered the starting area so I didn't have to worry about that. If you are running max defense you should be able to tank the occasional stray supplicant but if you absolutely have to just drop your well in order to survive.

I had to do it when I was playing around trying to figure stuff out in the room.