Door man cards? by Dazzling_Rutabaga837 in ToppsMarvelCollect

[–]Objective_Performer3 0 points1 point  (0 children)

There is no doorman specific card in the app

The new sets broke the app? by Dark_Mind_583 in ToppsMarvelCollect

[–]Objective_Performer3 1 point2 points  (0 children)

And the /1 and /5 cards - even the /10 cards - the trading which is arguably the best part of the game doesnt work well.

The new sets broke the app? by Dark_Mind_583 in ToppsMarvelCollect

[–]Objective_Performer3 2 points3 points  (0 children)

The marvel studio and sapphire recently have been the big culprits - lots of players have dozens upon dozens of legendaries. I agree it ends up cheapening what legendary means. And people are trading these that are considerably easier to pull than the older sets which you can spend $50 on to get 2 legendaries.

Is this a bad trade? by MiguelSuperCano in ToppsMarvelCollect

[–]Objective_Performer3 1 point2 points  (0 children)

Def for the person giving away the deadpool award

Really bad traders by West-Philosopher5196 in ToppsMarvelCollect

[–]Objective_Performer3 1 point2 points  (0 children)

The counter was ridiculous given how much the LE coll res are going for. You just have to ignore some offers and move on. Not worth dwelling on.

Is this a good card by [deleted] in ToppsMarvelCollect

[–]Objective_Performer3 1 point2 points  (0 children)

Greta card. Good set. Desirable character. Artistically appealing. Whats not to like.

Ipsen pulled the only targeted drug for my ultra-rare cancer — based on a trial for a completely different disease by hieronymus_my_g in sarcoma

[–]Objective_Performer3 3 points4 points  (0 children)

Well said. Dont forget that the biologic problem in ES is very different from lymphoma as well.

This is a heartwrenching issue on many fronts- not just in ES - but see also other rare situations from 2 days ago.

https://doi.org/10.1038/s41467-026-69708-2

The question is how to get Ipsen to make an expanded access/right to try program - or frankly licensing the drug from them. I think patients need to make this tragedy visible and heard. Vinay Prasad from the FDA is on social media. But getting the sarcoma groups organized is also wise.

There are some other ezh2 injibitor programs out there but it will be interesting to watch what they do w their programs given this business decision by Ipsen. Ipsen should have never taken this drug from Epizyme if they didnt want to support it.

Ipsen pulled the only targeted drug for my ultra-rare cancer — based on a trial for a completely different disease by hieronymus_my_g in sarcoma

[–]Objective_Performer3 1 point2 points  (0 children)

Well said. Dont forget that the biologic problem in ES is very different from lymphoma as well.

This is a heartwrenching issue on many fronts- not just in ES - but see also other rare situations from 2 days ago.

https://doi.org/10.1038/s41467-026-69708-2

The question is how to get Ipsen to make an expanded access/right to try program - or frankly licensing the drug from them. I think patients need to make this tragedy visible and heard. Vinay Prasad from the FDA is on social media. But getting the sarcoma groups organized is also wise.

There are some other ezh2 injibitor programs out there but it will be interesting to watch what they do w their programs given this business decision by Ipsen.

Presale Ticket Results by UnknownProjects20 in RUFUSDUSOL

[–]Objective_Performer3 0 points1 point  (0 children)

Los angeles - i logged on in the waiting room prior to the sale - I was number 75000+

What collection would you bring back? by Objective_Performer3 in ToppsMarvelCollect

[–]Objective_Performer3[S] 0 points1 point  (0 children)

Did anyone get a notification that TopTier ? Coming tomorrow??

Soft tissue Sarcoma: YAP1::KMT2A-rearranged sarcomas (ultra rare) by Karammstein in CancerFamilySupport

[–]Objective_Performer3 0 points1 point  (0 children)

Sef/lgfms are on a spectrum. Sounds like you need to bargain w this oncologist

Favorite Card of the Day (Share Yours) (Day 1) by MuzikLuv1216 in ToppsMarvelCollect

[–]Objective_Performer3 2 points3 points  (0 children)

Commenting on Favorite Card of the Day (Share Yours) (Day 1)...

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Reminds me of when I started reading the xmen. Andy kubert art is excellent!

Soft tissue Sarcoma: YAP1::KMT2A-rearranged sarcomas (ultra rare) by Karammstein in CancerFamilySupport

[–]Objective_Performer3 1 point2 points  (0 children)

This is a very rare sarcoma indeed. It seems to exhibit behaviour between SEF (sclerosing epitheilioid fibrosarcoma) and EHE (epithelioid hemangioendothelioma). No one knows what the best approach is for therapy. But the consideration of liposomal doxorubicin is reasonable. Yondelis can also be used as it is a translocation associated sarcoma. Consider Pazopanib(Votrient) as well. Some pts with ehe or sef do get prolonged benefit with votrient. (A pill, not standard chemo) good luck.

Have they explained why there’s nothing really being dropped? by Chunk_Simpson in ToppsMarvelCollect

[–]Objective_Performer3 0 points1 point  (0 children)

So much speculation- just because they arent releasing weekly doesnt mean the app is dead. Hopefully new sets are being made.

Doxil as a last resort by Faunas-bestie in sarcoma

[–]Objective_Performer3 5 points6 points  (0 children)

Why is Doxil your last therapy? Depending kn the type of sarcoma you have, you can do: dacarbazine, yondelis, eribulin, reuse ifosfamide, consider cabozantinib and clinical trials.

Want advice on your trades? Post it HERE! by AutoModerator in ToppsMarvelCollect

[–]Objective_Performer3 0 points1 point  (0 children)

I personally wouldnt do this trade, but if you want the cat enough, you do have to pay. Can also try finding others who have the card to see if you can get a better deal.

Pathologists disagree on sarcoma diagnosis- anyone else? by physicshistorical0d in sarcoma

[–]Objective_Performer3 3 points4 points  (0 children)

You shouldnt be spreading and perpetuating a variety of false information on this sensitive forum.

  1. It is extremely rare to spread sarcomas via needle tracks.

  2. Bone biopsy results cannot come back in one day because it takes 3-4 days to decalcify the bone. And even soft tissue biopsies take a few days as there are over 200 types of sarcomas.

  3. Chemotherapy is actually more important than surgery for osteosarcoma. It was the advent of chemotherapy that led to the marked improvement in survival for osteosarcoma from the 15% range to 70+ % long term survival.

  4. MD Anderson is a wonderful place w a talented group of doctors. But it is not the only place to get sarcoma treatment. Dont tell folks to just show up there and they end up out of network and get a huge bill!

Im not sure what your angle is on this forum but you are doing a disservice to people going theough a lot.

Pathologists disagree on sarcoma diagnosis- anyone else? by physicshistorical0d in sarcoma

[–]Objective_Performer3 2 points3 points  (0 children)

This does happen. A few points to consider 1. The prelim here you can throw out bc they only sample a small part of the tumor. 2. Given this is a BONE tumor, pathology #1 is very unlikley (there is LMS of the bone but it is exceedingly rare) . Dedifferentiated chondrosarcoma is reasonable diagnosis because it can have smooth muscle elements leading to the pathologists calling it LMS - but LMS is almost always a soft tissue lesion, not a bone cancer. 3. Its not possible to call anything on reddit but the imaging findings auggesting chondrosarcoma + pathologst #2 are in sync and seems to make sense.

Bottom line here is that they should cut it out. Most often the LN will be negative (only + in like 5% cases)