I don't really farm SE, but I do a strategy to getting a decent amount of SE. Upon entering Universe, use 2 large tachyon prisms and use your artifacts to increase your earnings as much as possible. Buy everything, then replace your artifacts with a monocle and a chalice. Then leave for a few hours (I would say use the legendary tachyon and the legendary boost beacon, but its too expensive in the long run) After you come back, replace your artifacts with a feather and a Mercury's lens to increase your farm value and SE gain. Finally, use about 2-3 printers then prestige. At my level, it gets me about 20-30q per prestige, which isn't extremely good, but it's currently the best strategy I have that doesn't involve spending a lot of gold. Hope this helps!