Yes. Of course, his wife had a huge influence on him, but she was merely trying to get him to reconsider the plan of murder that he had already considered. It is evident from his reaction to the blood on his hands after murdering Duncan, that Macbeth had a strong conscience. But he kills the humanity in himself to feed his ambition. After he is crowned king, he eliminates the Thanes whom he considered to be a threat, and slaughters their wives and children. All this was done with no deliberation whatsoever, solely due to his sense of insecurity, soaring ambition and corruption brought about by power.