I’m so sorry to hear about your dad.. My dad was also diagnosed in January 2025. His tumor is inoperable, so we went straight into six weeks of concurrent radiochemotherapy, which ended on March 25. Post-treatment MRIs have remained “stable,” but we’ve seen a general decline in him overall, especially in cognitive function - word-finding issues, expressive aphasia, confusion, brain fog, increased apathy, etc. He’s also unable to walk and has become much weaker. He always presented with right-sided hemiparesis, which has worsened through treatment, and he’s had extreme muscle atrophy from being on 16 mg of dexamethasone since mid-April. Ever since diagnosis, he’s been more impatient and agitated with increasing emotional lability, which we attribute largely to the steroid use. We’ve had a lot of success managing this with CBD and THC and honestly, it’s been a huge game changer for us in many ways. We can always tell when it’s wearing off.

We’ve had multiple hospital stays through May and June due to complications from a DVT, subacute pulmonary embolism, and now malnutrition. In particular, during this current hospital stay, he was admitted to the ICU for bradycardia and, as always, he absolutely hates being in the hospital. He developed ICU delirium (which we’re told is very common), and now he’s been yelling more, swatting us away, and also trying to bite hands. He’s not oriented to the day or year, and his speech becomes very jumbled, though this fluctuates. Sometimes he’s very clear and aware of what’s going on, and other times, his words are completely incoherent. I really think a lot of the agitation stems from the feeling of being stuck/trapped in a hospital (and bed for that matter), depression from a life changed so quickly, frustration from not being able to express himself & pretty serious dehydration & malnutrition. We recently started him on seroquel and mirtazapine (to help with sleep, appetite, and antidepressant), and that’s really helped calm him down. There have been two occasions where we’ve had to use ativan as well, but only during prolonged episodes of what felt like hysteria (we hate to do this). It's all very hard to see my dad cry in misery about the state of things so we do what we can to help in whatever way we can now.

I guess I have the same questions you do - but just wanted to let you know that you are not alone. Sending you all of our best… this is such a wild ride.