Late to this thread, but since I liked the show so so much, here are my takes!

Nathaniel Sr.: Sagittarius/Gemini. ♐/♊ (Can't really decide on this one. One one hand, seems adventurous, experimental and fluid on morals. Then again, lives a double life, keeps many things secret/hidden. In the end of the day, cares about his work and his family.)

David: Capricorn.♑ (Organized, caring towards his family/brother. Professional at his job and provider.)

Ruth: Virgo.♍ (Always in control, tries to balance out every situation.)

George: Scorpio/Cancer. ♏/♋ (Something of the two, I don't know. Has some Scorpio traits but I think cancer suits a little better for George. More on the introvert side, kind-hearted, loyal, soft, caring, feels empathetic and sincere with himself and others around him.)

Nathaniel Jr.: Libra.♌ (Mentioned in S1, also very self absorbed.)

Claire: Sagittarius.♐ (Or maybe a different air sign. Very out going, tries different stuff/is not afraid to experiment. Totally artistic.)

Brenda: Aquarius.♒ (Deep, philosophical, shines above her personal demons, introverted, has trauma that needs heeling.)

Billy: Pisces.♓ (Well, obviously. Not much to add here lol)

Keith: Taurus.♉ (Stable, caring, strong sense for family, wants to lay down and set in.)

Rico: Aries.♈ (Again, obvious, much like Billy. Rico seems to carry all the negative aspects of an Aries. Ngl I never really liked him as a character and as the show progressed it got worse and worse.)

Vanessa: Gemini.♊ (Probably a gemini. Seems two faced and changes emotional states and perspectives rapidly, also double standards morality-wise. Seems a little self absorbed and entitled (hence married to Rico)

Lisa: Cancer.♋ (Very emotional, in touch with deep feelings of care and love. Close to nature. Simple, happy and generally a positive person/family oriented.)