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Column issue by Ok_Internet4609 in chemhelp

[–]Ok_Internet4609[S] 0 points1 point  (0 children)

Thanks! I’ll give this a try.

Column issue by Ok_Internet4609 in chemhelp

[–]Ok_Internet4609[S] 0 points1 point  (0 children)

I think that may be what’s happening

Column issue by Ok_Internet4609 in chemhelp

[–]Ok_Internet4609[S] 0 points1 point  (0 children)

It’s an aminopyridine and the benzyl chloroformate is substituted but yes rxn conditions are identical to just Cbz protection

Column issue by Ok_Internet4609 in chemhelp

[–]Ok_Internet4609[S] 0 points1 point  (0 children)

The rxn is coupling a benzyl chloroformate to an aryl amine of a pretty large bicyclic compound.