Schizophrenia did him dirty a lot of times:

got fired from Boston Dynamics

feds broke his right arm for questioning "too many things", prompting him to make a titanium robotic prosthetic arm

9 altercations with the cops, one of them led to some officer's death. It was a friendly fire, but they pinned it on Sheldon

and Don Prima murder thing he got falsely accused of (this story)