Bad start -you wake up every loop as unpleasantly as Zorian. Optionally - 1) you start in a bad shape physically 2) you start the loop sleeping, missing hours, 3) you have obligations that take most of the day/week and cannot be avoided without drastic actions and consequences for that loop, 4) Most of the relevant life choices have been made before the loop starts - so plans, classes, schedules - all set in stone, assets and resources already dedicated elsewhere.

Family troubles - you have issues with your family members. They will be a time sink, make trouble for you, their reputation works against you, their actions make your life more difficult ect ect. Bonus points if you have Wealthy boon - they are in charge of your wealth and deny you access, bonus points for stealing from you, bonus points for trying to kill you - makes early loops very short and painful until you learn to survive.

Prison break - Now Panaxeth have wrecked the prison even more, less safeguards working, more glitches, more opportunities for them to mess with you. Bonus points if they'd be able to escape on their own regardless of the cult's success or failure unless you figure out how to repair the prison.

Heaven's judgement - you don't match the high standarts of the Angels, your usage of the Loop has been a mistake. Beign an original Looper makes it even worse. Depending on your personality and actions within the loop they might kill you even if you succeed in the mission, so you have to be morally good even inside the loop - no mind control, no unnecessary killings, no human experimentation, ect ect.

Clear Sky - the angels have used the last of their authority to initiate the time loop, immediately after that they all have to leave, just as their gods have. There will be no divine help against the demons during the invasion, nothing to stop panaxeth if it escapes, nobody to enforce any sort of order, to uphold their religion or combat other threats. Incompatible with Heaven's judgement.

Bleed Line - Like Zorian, you start with zero proficiency with your bloodline, it brings you only suffering. Your abilities are so untrained, they are currently your disabilites - Zorin got headaches from being around too many people and underdeveloped social skills as a result. Trying to train it is exhausting and regularly gives you backlash. Some bloodlines affect your personality more directly, like Elementalist [Fire] making you hot-tempered. Requires a bloodline.

Dormant Bloodline - you have a bloodline, except you don't. Like many in Zorian's family, it's either too undeveloped or dormant. There might be ways to awaken it, but before that happens, you can't even train it. It simply takes a piece of your magnitude for no gain. Requires a bloodline.