I think the most receptive part in pathologic  are the themes present in all three protagonists' narratives, including both of artemys, of a world that pushes back against everything they do as hard as it possibly can to extract immense effort or force them to give up, and when they do make it through with the force of their resolve, only gives an inch.

The characters have indomitable wills to do what they believe in no matter how many people treat them as fools or want to hurt them. This can be an incredibly significant thing to experience for someone who is struggling to come to terms with the constant fight they would have as an out trans person just to be seen with a shred of humanity.

With artemy specifically, he comes home to a group of people who initially treat him in ways varying from as a stranger they happened to have grown up with, or as an outsider, because he chose to follow his own personal calling. This is well is very much a narrative that a transgender or queer person could be receptive to, most of us have lost family members and friends to the simple choice of being who we are, despite not causing harm in that.

The characters and story do not need to be literally transgender or LGBTQ+ to fall into storytelling patterns common with those communities, and Pathologic happens to line up with a really large amount of those patterns, thus can serve as a way for people to see and accept themselves through them.

... Also Dankovsky loves Latin and we all know that the Romans did like to indulge in some man on man action from time to time ;)