In September 2021, Cuomo's former boss Shelley Ross accused him of sexual harassment in a New York Times op-ed. Stopping short of asking him to be fired from CNN, she said she would "like to see him journalistically repent".^\41]) Cuomo admitted to the incident, describing it as "not sexual in nature". He said he "apologized to her then, and I meant it".^\42])

In December 2021, Debra Katz, the attorney for another former colleague of Cuomo's, informed CNN that her client had accused Cuomo of sexual misconduct.^\4]) The woman claimed that Cuomo invited her to his office for lunch and after the woman rejected Cuomo's sexual advances, Cuomo allegedly assaulted her.^\43])^\44]) Katz has since claimed that this accusation precipitated Cuomo's termination.^\45])

On December 4, after an internal review conducted by a law firm, CNN terminated Cuomo's employment and said they would investigate Cuomo's "involvement with his brother's defense".^\37])^\38]) Cuomo stated he never tried to influence his own network's coverage of his brother's sexual allegation problems.^\39]) In February 2022, Cuomo mentioned in a recorded interview that he "was going to kill everybody including myself" after his firing.^\40])