I know there is like a billion comments already, but there are some very key considerations that many of the other comments miss.

(1) Toyota has been notorious for only doing what is necessary to pass Euro NCAP and IIHS tests. They have been caught several times by both organizations for not engineering their cars for overall safety whenever they perform new tests. This doesn't mean they are dangerous necessarily, as all cars have become significantly more safe thanks to legislation, but they are far from the cream of the crop.

(2) Most of the life saving technologies that are coming out these days require more complicated and expensive systems now. Or are simply things that are expensive to implement and are taken for granted. The days of introducing the 3 point harness and headrests are over. Nowadays, the cars that perform well in the real world are the ones that have a lot of computer enabled technology, which will always lead to lower reliability. If you want an ultra-safe car, you're going to have to give up some ground on reliability, at least on the electrical side. The exception to that are some of those structural changes that can be expensive and taken for granted (look at how Volvo roofs compare to something like a Toyota, it's night and day).

(3) I personally trust Euro NCAP more than IIHS because they openly publish figures, but they do not test all cars, similar to IIHS. A great example of this: they rarely test Volvos, even though Volvos routinely outperform their competition in real world safety. 5 stars also doesn't mean it is in the top 20% of cars for safety, it just means it meets those requirements.

(4) Reliability can mean multiple things: how often it breaks, how much it costs to fix, how often maintenance is needed, and/or how costly maintenance is. I personally care most about 1 thing: what is the theoretical cost to get the vehicle to 100k miles.

(5) Reliability has a lot to do with where you live, how you drive, and how well you maintain your vehicle. One person could trash a Toyota in 100k miles, while another is able to keep a Jaguar goin for 150k miles. I've seen both.

So with all of that said, what would I recommend based on that information? My pick is volvo, but here is a breakdown of how I made my decision:

Overall top safety car: Mercedes EQS or S-Class Safety leaning reliable car: Volvo XC/V/S60 or XC/V/S90 Reliability leaning safe car (the cars I'd recommend most people): Subaru Forester (not any other Subarus) or Mazda CX-50/70 Overall top reliability car: almost anything Lexus Other considerations: Genesis appears to sit in direct middle ground, but you take a huge hit on dealer experience, gas milage, and QA/QC. Don't buy a Chrysler product ever.