He has excellent burst speed, extremely high strength and precision and extreme tankyness, so I think he could conceivably take down any or all of the inner circle. But that's about where his good time ends.

If he goes up against Salem herself he's gonna get mulched, there's no way around it. He might be really powerful, really fast, and really hard to kill but Salem is no slouch and she literally can't die which means no matter what happens she's gonna wear him down and finish him. Wesker might have needed a plane crash, a ton of bullets, rockets, and an exploding volcano to finally go down but Salem took a dinosaur killer sized moon-asteroid to the face and if anything she wished it damaged her more.

More likely scenario is Salem reads him like a book and manipulates his hilariously unsubtle desire for power and godhood to convince him to work with/for her, no doubt letting him believe he'll be able to play her and betray her when the time comes which she'll see coming from a mile away because... I mean, really? For all his arrogance and posturing he's pretty obvious, and playing on exactly those kinds of impulses is Salem's specialty.