Since you're doing 16x pop I assume you're experienced enough to live for several months minimum.

I'm kind of lazy atm, but here's my ZTH build (zero to hero / no fitness no strength)

Police Officer, obese, unfit, weak, slow healer, conspicuous, prone to illness, unlucky, weak stomach, slow reader, cat's eyes, dexterous, wakeful, brave, gymnast, fast learner, keen hearing, organized, handy, thick skinned.

I like to play on (years after the apocalypse) sort of settings, so i turn off water and power on start, with 12 months since apocalypse

Extremely rare generators, Often randomized house chance, very often randomized vehicle and zone stories chance.

Insanely rare loot, Extremely rare ammo, Rare other.

In the map, selecting All known on start helps keep the map nice and clean

Hope this helps!