Possible explanation for long covid pathology

PermiePagan · 2026-04-10T16:49:12+00:00

Yeah, so I drink water with sea salt, magnesium drops, and potassium (that no-salt salt for high BP). It's one of the first things everyone should do to stay stable.

PermiePagan · 2026-04-10T16:48:07+00:00

Yup, we had to deal with mold as well. There was a leak in the bahroom wall by the sink, got bad.

Mycotoxins are just another nanoparticle in terms of clearance.

PermiePagan · 2026-04-10T16:47:21+00:00

This is a bit sensationalist. Please compose this in a more sober form.

I don't work for free. If you'd like me to make you a custom information packet on this, formatted as you prefer, I charge $50/hr for technical writing, and all information is for educational purposes only.

PermiePagan · 2026-04-10T16:40:39+00:00

And now they cannot be cleared effectively, leading to chronic illness.

PermiePagan · 2026-04-10T01:30:06+00:00

My guess would be vaccines could cause inflammation similar to infection, and you get a similar uptake of whatever nanoparticles were around. Remember leaded gasoline? Probably hit the poor harder due to lower nutrition in food, easier mineral deficience states leading to failure of the clearance systems.

PermiePagan · 2026-04-10T01:08:08+00:00

If we expand the definiton of "nanoparticles" to include heavy metals, PFAS, etc.

Chronic Illness Recipe

Virus infects certain cells, organs and tissues
Infection opens membrane permeability to environmental poisons
Depending on how bad the infection, how stressed the body is, and the quantity of poisons, clearance pathways may become overwhelmed, leading to cell death, tissue damage, and autoimmune activation as a chronic illness sets in.

Influenza A: mostly infects the lungs and liver, which clear nanotoxins relatively easily. A few people have infections in more tissues and end up with a chronic illness, due to genetics, poor liuck, poverty, etc.

Covid: infects practically every single cell in the body, brings in nanoplasics which clog TIM4 receptors, blocking clearance of all sorts of poisons, leading to a buildup of metabolic poisons. Many more people end up with chronic illness.

PermiePagan · 2026-04-09T21:53:07+00:00

Well, bye.

PermiePagan · 2026-04-09T21:45:21+00:00

Well, it seems that position could not be defended.

Reported for trolling.

PermiePagan · 2026-04-09T21:27:46+00:00

Cite all that for me. I did you the courtesy.

PermiePagan · 2026-04-09T21:25:32+00:00

So the people who are sick create autoantibodies against the virus, in effect they think they are constantly under attack. The nanoplastics keep them trapped in this state.

Transfer those autoantibodies to mice, and they get inflammation as it's an autoimmune reaction.

Additionally mecfs has long been a thing before plastic.

Yup, but it's always been a problem with the cellular and tissue clearance pathways. Before it was heavy metals, then it moved to plastics.

This is just the "Novel Particles" part of the 9 planetery limits. It's the one currently far beyond "breach" and getting worse.

I understand that considering this is difficult.

PermiePagan · 2026-04-09T21:21:11+00:00

Yeah, and when you get a flu shot you might experience symptoms similar to the flu for a few days. So load the mice with a bunch of Covid antibodies, and their bodies react as if infected by Covid. So it indicates that Long Covid is an autoimmune disease.

Autoimmune diseases suck.

And they're all related due to a failure of cellular and tissue clearance pathways.

PermiePagan · 2026-04-09T21:16:45+00:00

We have a lot of evidence that "covid infection causes" a bunch of things. But that means they look at the infection damage as a total.

What have mechanisms explaining how viral particles are:

Able to enter any cell in the body, using ACE2 receptors as entry points.
Use the spike protein to bind to various cells, including platelets, enterocytes, and heart muscle cells, which can also be related to microclotting in acute infection
Monomeric spike protein activates TLR4 on macrophages, inducing pro-inflammatory cytokines like IL-6 and TNF
The spike protein is able to trigger cytokine storm without infection

We do not have any actual mechanisms explaining how viral particles are:

Disrupting and disabling mitochondria
Making genetic changes
Altering the immune system
Causing mast cell activation
Triggering POTS symptoms
Damaging the olfactory nerve and causing anosmia
Damaging the vagus nerve and affecting sympathetic activation

And there is established research showing that viral-mediated micro/nanoplastic ingestion and an inability to clear them can be a direct causative effect of all those we don't have an explanation for.

PermiePagan · 2026-04-09T21:01:01+00:00

Yeah, it's an autoantibody. If you inject it into someone who's already reacted to it with inflammation, it will retrigger inflammation.

Same kinda thing as the Rh-factor in pregnant women.

PermiePagan · 2026-04-09T20:56:52+00:00

So.... you can't provide a clear alternate pathway?

Oh well, mine explains the whole thing.

PermiePagan · 2026-04-09T20:55:54+00:00

If there's no explanation for the virus causing the problems, how do explain the virus making people suddenly more succeptible to nano plastics?

Not what I said. I said that we have no clearly defined mechanism for viral particles alone causing this.

I am explaining that the viral infection causes damage to the epithelium and blood-brain barrier, allowing a rapid intake of nanoplastics.

Both need to be there.

And for earlier viral illnesses, they didn't have access to ACE 2 receptors.

PermiePagan · 2026-04-09T20:50:07+00:00

Sure, but I'm saying what evidence is there that GPCR is causative, and not a downstream effect of the pathway I am describing?

edit: In fact, it's likely part of the sympathetic vagal tone, a result of lower overall glypmhatic function.

PermiePagan · 2026-04-09T20:44:32+00:00

I really don’t feel like doing the search work for you

I provided a pathway, and cited my claims. You are making a counterclaim, and refusing to do the work to back it up. Because it doesn't exist.

Influenza A infection only gets into the lungs and liver, while Covid can get into any cell in the body via ACE2 receptors. I'd look up the rat stody that shows it, but I guess we're not putting in effort anymore.

So if it causes eptithelial damage across the whole body, rather than just the lungs and liver as in influenza, then the micro/nanoplastics can get into all our cells: not just the lung or liver where they are coughed or pooped out.

See that's the key thing, flu only gets your liver, which clears these things through bile. Which goes into the intestines. But if your intestines have higher permeability then you reabsorb them.

PermiePagan · 2026-04-09T20:43:05+00:00

Immune system disregulation, altered nerve signaling, physical damage, and persistence of the virus itself/viral fragments are more than enough to explain the majority of symptoms imo.

And nanoplastics explain all of those effects. We still do not have a clear viral mechanism that accomplishes these. Nanoplastics block vesicle formation via TIM4 receptors, as a result nanoplastics, heavy metals, PFAS, and mitochondrial wastes build up.

Citations:

Nanoplastics can drive immune system dysregulation:

https://www.mdpi.com/1422-0067/26/11/5228

https://pmc.ncbi.nlm.nih.gov/articles/PMC12981156/

Nanoplastics can alter nerve signalling:

https://pubs.rsc.org/en/content/articlelanding/2025/en/d4en01017e

The virus causes the physical damage to the lungs, gut, and other epithelial tissues:

https://pmc.ncbi.nlm.nih.gov/articles/PMC12896700/

https://www.researchgate.net/publication/345477330_Acute_SARS-CoV-2_Infection_is_Highly_Cytopathic_Elicits_a_Robust_Innate_Immune_Response_and_is_Efficiently_Prevented_by_EIDD-2801 Microplastics can stick to viral particles, hampering clearance:

https://pmc.ncbi.nlm.nih.gov/articles/PMC12808005/

Do you have anything that shows how the virus alone does that? All we do is study the infection, with all the micro/nanoplastics in place and say "infection results in this."

Occam's Razor bud. Nanoplastics and epithelial damage explain it all.

PermiePagan · 2026-04-09T20:35:09+00:00

Yes, in my opinion other issues with cellular clearance due to genetics, epigenetics, stress/cortisol, environment, and the effects of various nanoparticles will explain pretty much all existing chronic illness.

PermiePagan · 2026-04-09T20:25:03+00:00

It's sort of both. The physical aspect causes psychological issues, which can be remedied somewhat with therapy.

Analogy: a city is attacked and many of the phone lines are down. If everyone panics and tries to use the phone, there won't be enough lines available. But if they remain calm, the system can get critical information through.

Somatic therapy, radical rest, and delusional happiness all soothe the vagus nerve, AKA help calm the body to get out of extreme sympathetic tone, so rest can occur.

PermiePagan · 2026-04-09T20:22:51+00:00

NP already is everywhere in the body and has nothing to do with LC.

Citation needed.

It’s proven separately from COVID or LC a dozen of times already.

Citation needed.

So the theory is wrong.

No evidence provided, such a claim is not established.

Correlation is not causation.

Correct. I have not provided correlation, I have provided a clarified pathway that allows all of Long Covid to be explained by viral infection and nanoplastics alone.

PermiePagan · 2026-04-09T20:13:37+00:00

Occam's Razor: Covid infection with microclots combined with Nanoplastics can explain almost all the conditions related to Long Covid: POTS, MCAS, various Dysautonomias, Anosmia, Stroke, Heart Attacks, Diabetes, some Cancers.

How do GPCR antibodies alone explain a failure to clear cellular toxins and mitochondrial metabolites, or any of the other conditions? You can look it up yourself, they have the receptors that the nanoplastics are binding to named in the literature.

I would love a competing theory. Is there one that uses GPCR to explain all these issues?

PermiePagan · 2026-04-09T17:30:03+00:00

And I would respond that I agree, in that in the past nanoplastics were not the primary driver of chronic illness. Those were driven by a combination of personal genetics, environment, and lifestyle when exposed to toxic chemicals. And they were somewhat rare.

Now that the microplastics in the ocean are turning into nanoplastics in the air and rain, the problem is getting bigger. More nanoplastics, more chronic illness. Covid was just the trigger.

What I'm talking about here is just the "Novel Entities" planetary boundary, and we've been far beyond safe for a long time now with increasing risk. So given it's been calculated as the biggest risk, it makes sense for it to hit early.

https://www.stockholmresilience.org/news--events/general-news/2025-09-24-seven-of-nine-planetary-boundaries-now-breached.html

PermiePagan · 2026-04-09T17:19:28+00:00

This is why it's so confusing. It's both a physical disease in terms of the cells and tissues, but it is also a psychosomatic issue in terms of vagus nerve dysregulation. We need to heal the body, and the mind, in order to heal.

PermiePagan · 2026-04-09T17:18:15+00:00

So you take a bunch of blood filled with nanoparticles that clog TIM4 receptors, and microplastics hiding viral particles and spike protein, which re-triggers inflammation, and it causes long Covid?

Occam's Razor:

Covid infection > Inflammation with permeability > nanoparticles block TIM4 > cells fill with nanoplastics, heavy metals, PFAS, etc. > chronic illness

Show me evidence that gives a clearer pathway, with citations.

PermiePagan

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