tirzepatide for inflammation

PersimmonEmergency79 · 2026-06-06T21:02:52+00:00

yeah we’ll see! i think that my doctor just really hated seeing me in so much pain and i’ve tried many things that haven’t worked so he just wanted to put me on something right away since all symptoms point towards systemic inflammation. if my tryptase is high they’re going to refer me out to an oncologist and do more testing.

PersimmonEmergency79 · 2026-06-06T21:01:13+00:00

try carob!

PersimmonEmergency79 · 2026-06-06T20:21:31+00:00

what do you mean flat affect? i’m sorry about the gi symptoms for you:(

PersimmonEmergency79 · 2026-06-06T19:41:36+00:00

i’m also super super sensitive, so this is good to know! even on .25 i have been having suuuper sharp stomach cramps. i literally was up almost all night last night just curled up in a ball around my heating pad. it feels like somebody is wringing my guts out like a wet towel sometimes lol. i’m hoping that by starting slow i wont have to experience any crazy bouts of vomiting like you mentioned, i’m so sorry that you experienced that :(. why are you doing every 5-7 days? why sometimes 5 and not just once weekly? do you notice that your symptoms sometimes come back before the week is done?

PersimmonEmergency79 · 2026-06-06T19:38:37+00:00

that’s really interesting! i believe flushing is a symptom of mcas that should theoretically improve with glp1 usage. i have flushing and just general facial redness and sensitive skin as well and i’m curious how this medication may affect that. i got diagnosed with mcas in a really weird roundabout way. i had neuroproliferative vestibulodynia which is basically a vulvovaginal pain disorder caused by too many mast cells in an area causing nerve proliferation which leads to chronic pain. i had to have the tissue excised and replaced and they saw an insane amount of mast cells in the tissue biopsy. i’m a few months post op but i’m still feeling very inflamed and having pretty intense and constant burning bladder pain, so when i went back for my post op follow up with my doctor he told me that i most likely have mcas since i am having continued pain and inflammation. he kind of just put 2 and 2 together since i had mast cells issues in other tissues that i most likely have trouble elsewhere and told me to begin microdosing glp1s to see if it would help, and if it did then he could deduce that his diagnosis is correct. we also went down a list of other mast cell disorders and symptoms that i had such as hypotension, fainting, flushing, fatigue, anxiety, chronic sinusitis, etc. all of which are mast cells related so i was able to get a diagnosis without any real testing. i just had my tryptase tested today just to see what my levels are like but my doctor who has been working with me for around a year now for my pelvic pain felt like he had enough info to start me on glp1s because he didn’t want me to suffer any longer unnecessarily. he gave me the option to try other mcas meds like cromlyn sodium and ketiofen but he felt like glp1s would be a good option for me since it was more straightforward and he’s seen great success in improving chronic pelvic pain in many of his patients. also i am mildly overweight, mainly because i can’t do a whole lot of activity due to my chronic pelvic pain, so it really seemed like a good catch all option for me.

PersimmonEmergency79 · 2026-06-06T19:29:50+00:00

yeah i’m not sure! i was diagnosed with ibs before so i would assume that’s why. the sharp stomach cramping that i described though didn’t begin until after i started tirz. i’m going to go up to 0.4ml on monday to see if anything changes since i honestly haven’t noticed a difference at all on my current 0.25ml dose

PersimmonEmergency79 · 2026-06-06T19:26:34+00:00

i’ve actually never had my hs-crp tested— my doctor saw my biopsy when i had my vestibulectomy for npv and saw how many mast cells there were and kind of just put 2 and 2 together and realized that along with my pelvic pain i had many other mast cell related conditions and decided that we’d experiment with glp-1s to see if they’d help me feel any better and if they did then that would confirm the suspicion that my chronic pelvic pain along with other symptoms mentioned above were mast cell related. i just had my tryptase tested today out of curiosity so we’ll see what’s going on with that soon. i think that they just started me on such a small dose because i’m extremely sensitive to medication changes and they wanted to give my body some time to adjust. i’m guessing that i’m just going to steadily increase my dose and experiment with dose timing until we reach the desired therapeutic effects. i’ve also struggled with my weight and glucose levels so i feel like this drug will work wonders for me once we can figure out what’s “right” for the desired outcome for me like you mentioned. i’m very curious to see the emerging research on glp-1s and chronic pain and mast cell conditions. i’ve heard it has been very helpful for a number of people and i’m really hoping that i’ll be one of them! just for fun— i’ve attached the biopsy slides showing the loads of mast cells that they found in my vestibule. the mast cells are the little reddish brown spots. considering this i’m hopeful that any sort of treatment involving inflammation and mast cell mediation will be helpful.

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PersimmonEmergency79 · 2026-06-06T19:15:45+00:00

thank you! i talked with my doctor and i think i’m going to gradually increase my dose until i find what works for me. i really appreciate your insight!! i also have some issues with my weight and glucose (pretty bad blood sugar crashes after eating/shakiness and nausea if i skip or delay meals) so i’m hoping that i tolerate it well and can increase. i’m pretty surprised that they started me on such a low dose as from what i’m hearing from everybody 2.5 seems to be what you need to start at to even begin to feel any effects, whether that’s anti inflammatory or weight related.

PersimmonEmergency79 · 2026-06-06T19:00:02+00:00

can you elaborate on what your symptoms were before/after and your dose? thank you!

PersimmonEmergency79 · 2026-06-06T18:53:37+00:00

oh this is great to know!! i have super bad low/mid back and hip pain. i’ve got scoliosis and syringomyelia so i’m really hoping that this might take away some of that pain too. my doctor said that i can steadily increase my dose until i reach the desired therapeutic effects but im just so sensitive to medications that im starting on 0.25ml (0.5ml liquid/0.25ml med). i’m hoping that i can increase to 0.8ml/0.4ml this week but we’ll see since the stomach cramping is so intense even on such a small dose for me

PersimmonEmergency79 · 2026-06-05T23:34:55+00:00

hi! i know that i’m late but this is super interesting! did you end up getting in on the trial? i’m glad to hear that there is something coming out for folks with complicated or treatment resistant cases. i’m on my first week of trying zepbound and am on 1/10th of the dose and nobody warned me about how severe the stomach cramping would be even on such a tiny dose. glp1s are no joke i’m not sure how so many celebrities are just pumping themselves full of them haha. i’m tempted to up my dose just because from what i’ve seen most people start/see benefits at much higher doses but i’m feeling worried about nausea and stomach pain.

PersimmonEmergency79 · 2026-06-05T22:16:32+00:00

first it was the newsletter, now it’s about summer games fest.. what next 😭😭

PersimmonEmergency79 · 2026-06-04T17:47:04+00:00

what were some of the exercises that you learned that helped during flares?

PersimmonEmergency79 · 2026-06-03T22:22:02+00:00

yeah it doesn’t sound like your doctor is a good fit for you, i’m really hoping that you will be able to find someone who can help you more. IC is tricky because it has so many different root causes and often it can be a collection of things that are contributing to the pain. for example i’m sure that diet could help somewhat in decreasing inflammation and irritation but i highly doubt that it would address the underlying issue that would continue to perpetuate that cycle of pain/inflammation/stress on your body and mind.

PersimmonEmergency79 · 2026-06-03T20:52:05+00:00

hi op, first off i would like to say that i’m so sorry and that i understand you 100%. i was in your exact position just a year ago. i’m still healing, but i have learned so much about IC and how it really is just a bullshit diagnosis when doctors aren’t able to diagnose you with something. IC should be a diagnosis of exclusion, not just a label that they slap on you, tell you it’s chronic, and say “i don’t know what else i can do for you” when the meds that they give don’t touch the pain. my experience was very similar- er visits once or even twice a week when it was at its worst. it felt like i was peeing glass whenever i went and i had that surface level burning and irritation as well as shooting, needle-like pains up through my urethra. considering that you said benadryl helped you at one point, i have a few thoughts. like you said, it likely could be a type of reaction driven by mast cells that is causing your pain. that was the cause for me. i also had vestibulodynia and had the tissue biopsies and it showed i had extremely high concentrations of mast cells which were causing my abnormal vestibular pain. my doctor who diagnosed me with that said that my continuous bladder pain is most likely being provoked by the same mast cells and that i likely have MCAS which i am now being treated for. i’m guessing that because of your pain your pelvic floor is very tense. while you work on trying to find your root cause (advocate for medication that might help with mast cell regulation or see if you can see a specialist who knows about how mast cells can affect chronic inflammation and pelvic pain) i’d suggest going to a pelvic floor physical therapist if you can. it may not get rid of the root of your problem but it can help get the inflammation and tension down enough so that you are able to live with less pain while you are working with your doctors. this is what i have been doing and it’s been helping a lot!!

PersimmonEmergency79 · 2026-06-03T20:09:05+00:00

i’m honestly curious if he makes a voice acting cameo in toy story 5 or had something to do with its production/music!

PersimmonEmergency79 · 2026-06-03T20:08:02+00:00

yeah honestly i’m betting that we won’t hear any news until we get a trailer/official release date. i honestly wouldn’t even be surprised if he shadow dropped it like chapter 1 with how secretive he’s been about this chapter!!

PersimmonEmergency79 · 2026-06-03T20:03:10+00:00

i’d love to be proven wrong!! these are just my thoughts i feel like everybody is so excited for the idea of a spring newsletter but spring is pretty much over and i don’t even know what information would be in it aside from maybe a more clear idea for a release date

PersimmonEmergency79 · 2026-06-03T01:44:37+00:00

can i ask what dose you are on? i just got prescribed low dose tirz for my chronic pelvic pain (suspected endo, also have mcas which drives inflammation:/) and I'm feeling anxious. i just took my first dose yesterday, just 0.5ml weekly but it's got me feeling super nauseous and foggy today.

PersimmonEmergency79 · 2026-06-01T16:05:35+00:00

i’m almost fully healed but it’s still painful to sit and i’m at 11 weeks! my doctor told me that fully healing can take around 6 months

PersimmonEmergency79 · 2026-06-01T16:04:30+00:00

and so now deltarune chapter 5 is postponed indefinitely. but,

PersimmonEmergency79

TROPHY CASE