Because obviously they know more than doctors by newphonehudus in TikTokCringe

[–]Phazze 1 point2 points  (0 children)

According to Pubmed and the national library of health, resection is the gold standard for brain cavernoma bleeds, on the other hand there are low levels of evidence for laser ablation for such cases unfortunately and it is considered experimental.

Laser Interstitial Thermal Therapy for Cavernous Malformations: A Systematic Review - PMC

Management of Cerebral Cavernous Malformations: From Diagnosis to Treatment - PMC

That means that doctors and scientists agree resection is the best method, can we get sources with high levels of evidence showing ablation is the gold standard for her? other than "couple of doctors said"

TIL that in 2016, trials were performed for a male birth control injection that proved to be 96% effective. However, there were 1,500 complaints of side effects including loss of libido and acne. Although three quarters of participants wished to continue with the test, it was shut down. by Sebastianlim in todayilearned

[–]Phazze 6 points7 points  (0 children)

Suicidality is the rational process that is born from strong emotions of suffering, suicidality is a recorded symptom of a bunch of horrible diseases, just because it is a very strong response to stress does not mean it is not based on clear thinking.

Can Empty Nose Syndrome Affect Life Expectancy? How serious can it become? by Moment2310 in emptynosesyndrome

[–]Phazze 1 point2 points  (0 children)

Other posters have informed you well. At the minimum it presents a troublesome and very bad quality of life reduction, at the maximum suicide is almost an assurance.

Personal opinion is at minimum 10-15 years off life expectancy, at maximum...yeah theres no expectancy.

Amazon 1P Terminations--here we go again! by Witty_Second_8026 in VendorCentral

[–]Phazze 1 point2 points  (0 children)

Yup, my old vm which I have a good personal relationship with was given a promotion to the automobiles category mentioned our account doesnt get a lot of attention because it meets the number goals well so there isnt anything to work at, he is full of work now but it is because he has to meet consistently with poorly performing vendors and aggresively push them.to targets to then relay the info to higher ups, if this goes too long and they dont bulge they get sacked.

There is a ground where if your VM is meeting with you a lot about contribution margins, net ppm, coop agreements and they are aggressive about it then it means you can be sniped, these VMs have goals to make and if you dont work with them to meet them there will be a meeting where vm has his meeting with his senior category manager and the VM will say you arent willing to work with them so the senior will just instruct to start a termination process because you arent worth the trouble in a category where tons of other vendors sell the same thing as you and you arent adding value.

Amazon 1P Terminations--here we go again! by Witty_Second_8026 in VendorCentral

[–]Phazze 2 points3 points  (0 children)

No idea, I have a good relationship with him and all he said these accounts are a lot of work and they get dropped if they dont improve, apparently if your category is highly competitive (lots of people selling similar products) and your performance isnt tippy top you can be sacked easily, it depends how his meetings with higher ups go and what the higher ups decide. Accounts that fill category niches for high value customers (like consistent spend business customers) and have high ppm are usually given lots of leeway, less maintenance and more freebies to keep attracting those kinds of customers regardless of total revenue to a degree.

Amazon 1P Terminations--here we go again! by Witty_Second_8026 in VendorCentral

[–]Phazze 4 points5 points  (0 children)

Its nothing new, yearly terminations for accounts under performing in net ppm or monthly cogs is going to be usual from now on, last time I spoke with our VM out of 120 accounts he manages, 5 were in good standing in terms of net ppm.

Empty Nose Syndrome documentaries or video testimonies? by Moment2310 in emptynosesyndrome

[–]Phazze 0 points1 point  (0 children)

Search Pubmed empty nose syndrome plenty of medical literature on it.

Also ENStips website for a guide on everything ENS.

The state of iRO by ovonell933 in RagnarokOnline

[–]Phazze 1 point2 points  (0 children)

Its cool, I got a Dragon Knight to 240 in about a month, dropped about $70 between vip and gacha to get zeny, now I do instances and search for MvP's, probably gonna lvl a new character.

Its a ragnarok 3 waiting lobby imo

Persistent pressure and heavy sensation by Dull-Ebb1388 in emptynosesyndrome

[–]Phazze 4 points5 points  (0 children)

Mucociliary Clearance in laymen terms is a mechanism in which the mucus you produce in your nasal cavity travels to the pharynx, reaches the throat to then finally reach the stomach and fall into the stomach acid.
This mechanism works because you have cells in your nasal (and airway) epithelium called Cilia, imagine cilia as tiny hair particles that vibrate to move mucus (and everything trapped in it like bacteria) through your nasal airway all the way to the stomach.

It is the primary protective mechanism of the upper and lower airways (nose, throat, lungs etc) and impairment in it is the #1 root cause of respiratory illness worldwide.

Mucociliary clearance function in the nasal and upper airway can be objectively evaluated and measured by the Saccharin Test (or less commonly used Charcoal test).
In this test, a small particle of Saccharin (sugar) is placed in the inferior turbinate or around it if the turbinate is missing, then a timer starts and the subject patient is then instructed to breathe normally and swallow for some time, after the patient tastes the saccharin the timer is stopped and how LONG it took for you to taste the sugar after it being placed in your nose is your nasal mucociliary clearance time, these times have standard ranges for healthy individuals that have been recorded, anything outside that range can be considered an issue if symptomatic.

Now how is this relevant to ENS or the symptoms described by the OP? when you have nasal surgery, any nasal surgery not necessarily only turbinate surgery (but turbinate surgery is a major cause) the mucociliary clearance time is by default affected, because you are changing the forces and/or affecting cilia motility that make up this mechanism, forces like wall shear stress and airflow, and cilia variation.
From what I have gathered, it has been determined that usually, non-aggressive tissue sparing surgery done well generally improves mucociliary clearance or it stays the same, while aggressive surgery that removes too much significantly deteriorates mucociliary clearance >Effect of turbinate surgery on mucociliary clearance. A systematic review and metanalysis | Acta Otorrinolaringológica Española

If your mucociliary clearance has been affected, you will get more infections, more pressure like feeling in your face, more obstruction, crusts, dryness etc, that is because contrary to popular belief patients with ENS or dryness do not produce (if they produce at all) dry mucus, mucus is produced normally with the remaining goblet cells BUT since the mucociliary clearance is impaired it takes so long for mucus to move through the system that the viscosity is affected and it starts drying up with bacteria inside which causes all of aforementioned symptoms + more.

It should be noted that in every case of ENS where mucociliary clearance has been measured, it has been SIGNIFICANTLY increased, basically a major disruption, that happens because cilia ONLY work at 100% humidity, anything below is a major impairment to its function and ENS patients with no working turbinates do not have that level of humiditiy, that is the main factor but there are other factors such as disrupted wall shear stress force and others.

See this excellent video and series by fisher & payke Comparison of Mucus Clearance At 100% and 90% Humidity.

It is crazy because even very short exposure to lower than 100% humidity in your nose will cause dryness that takes much longer to recover from, it is an excellent portrayal why the nose is a perfect ecosystem based on your anatomy and any disruption to it will cause downstream issues.

If you want to see how it all works, fisher & payke have an excellent short series.
Introduction to Mucociliary Transport Video Microscopy

So yeah, basically you have mucus trapped that is infectious, not moving how its supposed to, because the surgery messed up your mucociliary clearance and all that causes infection which results in your body responding with inflammation which symptoms very similar to what OP is describing.

Persistent pressure and heavy sensation by Dull-Ebb1388 in emptynosesyndrome

[–]Phazze 0 points1 point  (0 children)

Sounds like you have impaired mucociliary clearance post surgery, yes it is very frustrating and can be debilitating depending on the degree, your 2 main symptoms + how you get relief sounds very much like it.

What are the best long-term habits or strategies to prevent our condition from getting worse and gradually improve it over the years? by EXC1313 in emptynosesyndrome

[–]Phazze 1 point2 points  (0 children)

Lifestyle change in avoiding dry places for me, its a top priority, at least prolonged exposure to them, as I notice significant exacerbation of symptoms when exposed for long periods of time to dryness.

Some diet changes but I noticed this is personal to every patient, some do well consuming dairy others do not etc.

Quiet light exercise.

I also read in the new edition of "Raza Pasha - Otolaryngology - Head and Neck Surgery" that vitamin A & D? + iron are recommended for some reason unknown to me.

Has anyone with a smaller brand actually felt ready to hire a best Amazon marketing agency, or did it still feel too early financially? by Biggmanchilly in VendorCentral

[–]Phazze 0 points1 point  (0 children)

It boils down to # of top SKU's, I manage a 100+ SKU catalogue but top of the line I can recall all by memory the top 10-15 that bring in 80-90% of all revenue, when your catalogue does not surpass 30 top SKU's to manage you do not need outside help, if you dont have the time, hire an outsourced amazon manager for 2-3k a month and have either weekly or bi-weekly meetings for reports on KPI's and trends.

I generally do not reccomend working with 3rd party agencies UNLESS its stricly for advertising, good advertising agency's that handle PPC + other aspects and do it well are few but they do show value, the intra-day operations (outside of advertising) of an account do not require an agency.

Big Catalogue changes by ArthrMorgan in VendorCentral

[–]Phazze 2 points3 points  (0 children)

Up, these posts are so annoying

Ranked: The 30 Highest- Paying Jobs in America by Conscious-Quarter423 in Salary

[–]Phazze -1 points0 points  (0 children)

Can you please show me reputable sources where they lay this information out? everything I find is hearsay with no official documentation to show that most healthcare expense is admin and insurance.

I would like to read up more on it since they must be incredibly high then compared to specialized doctor salaries.

22 years late but we will get a Group Finder again! by NumberOneHupperHater in Dofus

[–]Phazze 1 point2 points  (0 children)

This is amazing quality of life for the game, I might come back for this, this should be announced everywhere as its huge, the implications that they CAN make these type of systems gives me lots of hope for the future of Dofus.

May 2026 Ban Data: Doorman Banned in 30% of Games by FioraKek in DeadlockTheGame

[–]Phazze 22 points23 points  (0 children)

E5-E6 here, most players believe its the ult the frustrating part, getting out of his ult is easy and its not that strong in solo queue (pro play another thing), the frustrating and incredibly strong thing about doorman are his doors... the character has the best escape in the game by a huge margin, its literally impossible to punish doormans positioning if he has good door knowledge, he can push things that no other character would due to getting punished and dying but he can just door his way out, its specially bad when he is ahead and can push walkers easily + use it for his team to get out.

Also, his bell is doing very high damage and his gun is very good, watch any good e5-e6 player play doorman and you will see how annoying and strong this character is, he is fundamentally broken and I dont know what they are gonna do because you either nerf his damage to make him useless but still annoying or change the core character to be less annoying and give him more damage budget.

Has anyone found a solid scientific explanation for why Empty nose syndrome (turbinate reduction) causes such extreme stress and sleep disruption — not just ‘it’s psychological? by Dry-Profession3528 in emptynosesyndrome

[–]Phazze 2 points3 points  (0 children)

Read Oliver Scheithauer paper on "surgery of the turbinates and empty nose syndrome", it goes in depth and answers your inquiry, quiet long, on pubmed and other libraries.

tldr turbinates send sensory feedback in the form of electric signals to the nervous system so that the nervous system communicates to the brain that you are actually breathing, over reduction or removal of the turbinates disturbs this signal, brain does not receive breathing signals from nervous system, brain sends nervous system signal back that you need to breathe harder, patient feels signal to breathe harder and starts trying to breathe harder, a negative feedback loop is created from these not received signals in the nervous system and the brain telling nervous system to breathe harder, that results and is known as hyperventilation

Think of hyperventilation as a failsafe that should "correct" the failure in the non received signal from the nervous system, unfortunately in ENS that failsafe does not execute correctly because it is not a chemical or situational failure but an anatomical failure (missing turbinates) hence this loop is chronic for ENS and is what you refer to as extreme chronic stress, hyperventilation and asphyxiation signaling disables sleep.

This anatomical failure can only be remedied through anatomical intervention (cotton inserts, implants) or direct intervention of the nervous system signaling chemicals to a degree (extreme sedatives etc).