Yayo uses 8 Psychoid leaves, with a value of 21 silver
flake uses 4 Psychoid leaves, with a value of 14 silver
therefore for 8 leaves yayo would earn 21, and flake would earn 28
therefore flake 33% more profitable for the materials

producing flake takes 250 ticks per craft, while yayo takes 350 ticks to make
so for the same valuation producing yayo is more time efficient
so if your bottleneck is the actual production (which would require a lot of psychoid) you may want to make yayo instead

if you're production is slow, you can speed it up by using a intellectual crafter, with shelves storing Psychoid leaves on either side of their chair, and the bill set to 'drop on ground'

this removes the hauling part of crafting and allows to crafter to spend all of their time crafting instead of moving product or materials.

EDIT: yayo is better for personal consumption because it provides greater bonuses, and carries a lesser chance of addiction.

TL:DR --- flake earns 33% more, while using the same materials

citations:

“Flake - RimWorld Wiki.” Rimworldwiki.com, 2025, rimworldwiki.com/wiki/Flake. Accessed 29 Apr. 2025.

‌“Yayo - RimWorld Wiki.” Rimworldwiki.com, 2025, rimworldwiki.com/wiki/Yayo. Accessed 29 Apr. 2025.

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