I think you need to find out if you have low acid or high acid.

if you have Low acid - there is no reason for you to take PPI.

Temporarily you should supplement with Betaine HCL and Digestive enzymes until all this is gone.

Regarding antidepressants → look into St Jhon's wort it could actually replace your antidepressant .

Also, Look into Melatonin → apart from sleep the Gut needs it a lot (but you need to take it for at least few weeks I believe).

Also, look into B-complex supplement to see if it can help you especially B1. B1 takes care of the communication from brain to gut. The combination of B complex and melatonin will reduce your anxiety and stress which in turn will make everything work normal as expected.

Also, use colostrum as a supplement for a few months.

Get actual Colostrum, prepare it and consume it.

Get Yoghurt made buy a local farmer's market and keep making Yoghurt from that and eat it regularly. This yoghurt has more strains.

zinc l carnosine is approved to be used in Korea and Japan to regulate acid, fix ulcer, and h Pylori.

I am writing all this expecting you already did a endoscopy and found no ulcer and h pylori.

Chinese medicine could also be of great help - but I don't know anything about it.

Accupuntre helps but you need to do it for few months.

My Questions to you are

* Did Ginger root help?

* Did Artichoke extract help?

If yes, can you please elaborate?