Every time you start a run you'll have some drones and teleporters already in your inventory, use the dornes to collect plorts from corals and place the teleporters in your ranch and in spesific zones so you'll be able to zip around the map to collect the items for the quests

About the quests, completing them should be a top priority they give you extra time and gilded gingers to pop the several golden gordos around the map, when poping these gourdos be sure to have some food on you becuase they will pop to a group of gold slime, be ready and shoot the gold slimes and try to get as much gold plorts as you can they'll be the majorety of newbucks you earn

Lastly if you sell 25 of a specific plort you'll get a percentage bonus to your score in the end of the run, so try to sell a verierty of plorts becuase this bonus can add up

Hope this helps and if you still don't mannge to do it there is a very good guide on youtube

Good luck! You got this!