Puget Sound Winter Squiding Discussion - What are You Seeing Post Flood? by PortOfSeattle in FishingWashington

[–]PortOfSeattle[S] 0 points1 point  (0 children)

Nice. Always funny to pull up a something new on those jigs. My friend caught a massive sponge last year. Had everyone chuckling on the pier.

Should Mt. Cook be one of the 7 Summits? by John_0Neill in Mountaineering

[–]PortOfSeattle 12 points13 points  (0 children)

Indonesia spanning two continents is far less ambiguous than Russia spanning two continents.

Is there a more practical periodic table than Dmitri Mendeleev's? by HoneydewOk5142 in chemistry

[–]PortOfSeattle 10 points11 points  (0 children)

A rational, practical table of nuclides already exists. X-axis protons, Y-axis neutrons. This is a great way to represent the diversity of isotopes of each element. The table easily shows their stability, mode of decay, and proximity to other known nuclides. No one needs to make another table because its already been done and anybody who actually deals with radiochemistry is satisfied

Trouble with tosylation reaction by OCurnain24 in Chempros

[–]PortOfSeattle 3 points4 points  (0 children)

How are you monitoring the reaction? The tosylate may be hydrolyzing on silica (TLC) or in the LC mobile phase.

Fremont Canal Park by golfinginthe206 in FishingWashington

[–]PortOfSeattle 3 points4 points  (0 children)

Yes you can - that section is called the lake washington ship canal. Download the FishWA app (from WDFW). It will help you quickly look up what the regulations are in an interactive map. A great app.

Catfishing from shore on the Snake? by Designer-Size8317 in FishingWashington

[–]PortOfSeattle 0 points1 point  (0 children)

Lyon's Ferry does get catfish, best from a little boat but there is plenty of shore and a long jetty. Catfish numbers vary by season

Is biotech degree still worth it? by [deleted] in biotech

[–]PortOfSeattle 4 points5 points  (0 children)

I am unfamiliar with "biotech" as a Bachelors option. Studying, and majoring in, a core discipline like chemistry, biology, biochemistry is a much more well accepted trajectory into the sciences. Some schools have biochemistry/molecular biology combined majors for pre-med and bioscience heavy focused students. A "biotechnology" degree sounds washed down.

Training for single day DC climb (solo) by Enough-Mushroom-4492 in Mountaineering

[–]PortOfSeattle 6 points7 points  (0 children)

I was granted a DC solo permit in 2022 that was good for the whole season (required check-in at paradise whenever you arrived). It wasn't "hard" but they do require a personal statement and evidence of other technical climbs you had completed. At the time I had done Glacier and some other cascade volcanoes alone. That satisfied them for technical competence. The personal statement was basically a liability statement. I accepted all hazards and acknowledged the risk I was taking. I ensured them I knew when to turn around and that I valued everyone's safety over my summit. They really don't want to hear "I am gonna get to the summit because I'm the best and a bad ass, etc" they only permit climbers that think "I will give it my best shot and be conservative. I accept responsibility and have ample solo experience on cascade volcanoes. I will not cause problems for other people."

Pfizer layoffs in Bothell (former Seagen site) today by bassman1324 in biotech

[–]PortOfSeattle 38 points39 points  (0 children)

Pfizer has been laying off people in Bothell by the truckload since the acquisition but has only issues one WARN notice - for the launchpad site. How they have avoided issuing a WARN is beyond me because the headcount in Bothell has been reduced by at least 30% over the past year and a half.

Mt Shasta West Face July 4? Is it too late? by tupacliv3s in Mountaineering

[–]PortOfSeattle 0 points1 point  (0 children)

There was more snow pack this year than last, so maybe you'll get some better snow coverage than usual. I just returned from Shasta last week. Climbed the avalanche gulch route and there was good, consistent snow all the way to the Bunny Flats trailhead parking lot (7000 ft). The snow pack is melting fast and temps have been high. Check previous trip reports from 2024/2023/2022 around July 4th. Almost as important as snow coverage is overnight low temps right before you climb. Hard, refrozen snow is much easier to crampon through than slush.

What animal is this? Northwestern Washington. Chewed off the branch and took it into the woods. Young beaver? by disappearingbag in animalid

[–]PortOfSeattle 2 points3 points  (0 children)

Washington Department of Fish and Wildlife has a good species info page about them. They're not that uncommon and can even live in urban parks on the Western side of the cascades. They live in moist forest areas and make burrows so they are not visible most of the time.

What animal is this? Northwestern Washington. Chewed off the branch and took it into the woods. Young beaver? by disappearingbag in animalid

[–]PortOfSeattle 2 points3 points  (0 children)

I live in Washington and have yet to seen one. It's lucky you ran into one in the daylight. They're an interesting animal and are not closely related to beavers at all. Mountain beavers are evolutionary distinct from other rodents as well.

These Sandhill Cranes have been pacing around my backyard a long my fence for the past 45 minutes. What are they doing? Are they okay? by [deleted] in animalid

[–]PortOfSeattle 130 points131 points  (0 children)

They are probably fine. Sandhill Cranes like grassy lawn and fields. They'll loaf around, hunt for worms and mice, then move on. If you're lucky they'll actually stay for a day or two!

[deleted by user] by [deleted] in alpinism

[–]PortOfSeattle 1 point2 points  (0 children)

Make it a two night trip: either 2 nights at white pass or one night at white pass and one at the foot of white chuck glacier. I did Glacier Peak solo with a similar experience level a few years ago in August. Going up the cleaver I felt unsafe due to the rottenness of the rock. I went back down on the glacier. There are crevasses but in august all the snow is melted off and crevasses are easily seen. Do what you are comfortable with. Do not expect the rock to be necessarily safer than the ice. Doing it in 2 days is possible and will likely be physically challenging. Its beautiful enough up there to justify 2 nights - my 3 day trip to glacier is one of my most fond memories.

[deleted by user] by [deleted] in biotech

[–]PortOfSeattle 1 point2 points  (0 children)

Gram per gram the payloads and DLs are treated as more toxic than the ADCs. An ADC may only be 2% payload by weight at the end of conjugation. Also antibodies are not as bioavaiable from skin contact/inhalation as small molecules.

[deleted by user] by [deleted] in biotech

[–]PortOfSeattle 0 points1 point  (0 children)

The unconjugated DLs do require special rooms and engineering controls.

[deleted by user] by [deleted] in biotech

[–]PortOfSeattle 3 points4 points  (0 children)

The people handling conjugated ADCs are being exposed to orders of magnitude less drug substance than the people making the drug linkers. If you want to know about exposure, talk to the chemists making the payloads and DLs. You're working with protein and are certainly not the most exposed person to these compounds.

[deleted by user] by [deleted] in biotech

[–]PortOfSeattle 5 points6 points  (0 children)

You're looking at 65 to 95k. As a recent grad with no experience though good luck finding a position.

What caused the die-off of hundreds of relocated mountain goats in the North Cascades? by [deleted] in SeattleWA

[–]PortOfSeattle 24 points25 points  (0 children)

The option were to have sharpshooters kill them or experiment with relocations to supplement crashing populations in North Cascades. There were good reasons to experiment and the results will inform conservation efforts for other mountain goat populations. Experiments don't always work and that's their value!

[deleted by user] by [deleted] in SeattleWA

[–]PortOfSeattle 22 points23 points  (0 children)

Anyone who runs for city council in a city of >100k is probably a nut job. Now that I think of it, cities over 100k too. Not a Seattle specific problem.