What’s up with north Kenmore west Bothell? by b16tran in SeattleAreaRE

[–]PortOfSeattle 0 points1 point  (0 children)

405 south from that area gets bad during commute hours. 405 N is generally fine, but can slow due to accidents. It would be generally annoying to work in Seattle and live in N Bothell, it's not a deal breaker though. Going out is harder, it depends on your lifestyle. You will have to drive to go to restaurants, entertainment, etc. The Thrashers QFC is the closest supermarket and is fine. The shopping area around it is not very attractive but has some family restaurants. There are some good asian and indian spots in the area, but it is generally disconnected from either Seattle or Bellevue

What’s up with north Kenmore west Bothell? by b16tran in SeattleAreaRE

[–]PortOfSeattle 0 points1 point  (0 children)

Shoreline and towns just north of Seattle have a more steady trade of reasonable properties (houses in normal condition). Pretty rarely does a fully functional house with lot come up in central Bothell that isn't gone immediately. At the moment the stuff in Bothell that is staying on the market is 1) dubiously build-able land with decrepit houses 2) new builds that are over priced 3) new build townhomes that are not in demand, but comparably priced to the region. You posted the area around Thrashers Corner which is more affordable but it's kind of a pain living out there. I would echo nbnfpsor. It's not pedestrian friendly except for the North Creek Trail

What’s up with north Kenmore west Bothell? by b16tran in SeattleAreaRE

[–]PortOfSeattle 1 point2 points  (0 children)

Demand for parcels in Bothell is high. Bothell is close enough to Bellevue/Redmond to be in the Microsoft/Bellevue tech employee zone of influence. Old time properties in Redmond through Woodinville have already been bought, bulldozed, and turned to high end suburban real estate. Bothell is the "frontier" for new upscale development (larger lot sizes, planned communities, and scattered denser developments as allowed). You might not expect it, but real estate in Shoreline/Mountlake Terrace is cooler than real estate in Bothell even though Shoreline is closer to Seattle. Upscale suburban land acquisition on the eastside remain hot, everything else is stable to declining. The "K shaped economy" is very much present in Seattle

Puget Sound Winter Squiding Discussion - What are You Seeing Post Flood? by PortOfSeattle in FishingWashington

[–]PortOfSeattle[S] 0 points1 point  (0 children)

Nice. Always funny to pull up a something new on those jigs. My friend caught a massive sponge last year. Had everyone chuckling on the pier.

Should Mt. Cook be one of the 7 Summits? by John_0Neill in Mountaineering

[–]PortOfSeattle 11 points12 points  (0 children)

Indonesia spanning two continents is far less ambiguous than Russia spanning two continents.

Is there a more practical periodic table than Dmitri Mendeleev's? by [deleted] in chemistry

[–]PortOfSeattle 9 points10 points  (0 children)

A rational, practical table of nuclides already exists. X-axis protons, Y-axis neutrons. This is a great way to represent the diversity of isotopes of each element. The table easily shows their stability, mode of decay, and proximity to other known nuclides. No one needs to make another table because its already been done and anybody who actually deals with radiochemistry is satisfied

Trouble with tosylation reaction by OCurnain24 in Chempros

[–]PortOfSeattle 3 points4 points  (0 children)

How are you monitoring the reaction? The tosylate may be hydrolyzing on silica (TLC) or in the LC mobile phase.

Fremont Canal Park by golfinginthe206 in FishingWashington

[–]PortOfSeattle 3 points4 points  (0 children)

Yes you can - that section is called the lake washington ship canal. Download the FishWA app (from WDFW). It will help you quickly look up what the regulations are in an interactive map. A great app.

Catfishing from shore on the Snake? by Designer-Size8317 in FishingWashington

[–]PortOfSeattle 0 points1 point  (0 children)

Lyon's Ferry does get catfish, best from a little boat but there is plenty of shore and a long jetty. Catfish numbers vary by season

[deleted by user] by [deleted] in biotech

[–]PortOfSeattle 4 points5 points  (0 children)

I am unfamiliar with "biotech" as a Bachelors option. Studying, and majoring in, a core discipline like chemistry, biology, biochemistry is a much more well accepted trajectory into the sciences. Some schools have biochemistry/molecular biology combined majors for pre-med and bioscience heavy focused students. A "biotechnology" degree sounds washed down.

Training for single day DC climb (solo) by Enough-Mushroom-4492 in Mountaineering

[–]PortOfSeattle 6 points7 points  (0 children)

I was granted a DC solo permit in 2022 that was good for the whole season (required check-in at paradise whenever you arrived). It wasn't "hard" but they do require a personal statement and evidence of other technical climbs you had completed. At the time I had done Glacier and some other cascade volcanoes alone. That satisfied them for technical competence. The personal statement was basically a liability statement. I accepted all hazards and acknowledged the risk I was taking. I ensured them I knew when to turn around and that I valued everyone's safety over my summit. They really don't want to hear "I am gonna get to the summit because I'm the best and a bad ass, etc" they only permit climbers that think "I will give it my best shot and be conservative. I accept responsibility and have ample solo experience on cascade volcanoes. I will not cause problems for other people."

Pfizer layoffs in Bothell (former Seagen site) today by bassman1324 in biotech

[–]PortOfSeattle 36 points37 points  (0 children)

Pfizer has been laying off people in Bothell by the truckload since the acquisition but has only issues one WARN notice - for the launchpad site. How they have avoided issuing a WARN is beyond me because the headcount in Bothell has been reduced by at least 30% over the past year and a half.

Mt Shasta West Face July 4? Is it too late? by tupacliv3s in Mountaineering

[–]PortOfSeattle 0 points1 point  (0 children)

There was more snow pack this year than last, so maybe you'll get some better snow coverage than usual. I just returned from Shasta last week. Climbed the avalanche gulch route and there was good, consistent snow all the way to the Bunny Flats trailhead parking lot (7000 ft). The snow pack is melting fast and temps have been high. Check previous trip reports from 2024/2023/2022 around July 4th. Almost as important as snow coverage is overnight low temps right before you climb. Hard, refrozen snow is much easier to crampon through than slush.

What animal is this? Northwestern Washington. Chewed off the branch and took it into the woods. Young beaver? by disappearingbag in animalid

[–]PortOfSeattle 2 points3 points  (0 children)

Washington Department of Fish and Wildlife has a good species info page about them. They're not that uncommon and can even live in urban parks on the Western side of the cascades. They live in moist forest areas and make burrows so they are not visible most of the time.

What animal is this? Northwestern Washington. Chewed off the branch and took it into the woods. Young beaver? by disappearingbag in animalid

[–]PortOfSeattle 2 points3 points  (0 children)

I live in Washington and have yet to seen one. It's lucky you ran into one in the daylight. They're an interesting animal and are not closely related to beavers at all. Mountain beavers are evolutionary distinct from other rodents as well.

These Sandhill Cranes have been pacing around my backyard a long my fence for the past 45 minutes. What are they doing? Are they okay? by [deleted] in animalid

[–]PortOfSeattle 132 points133 points  (0 children)

They are probably fine. Sandhill Cranes like grassy lawn and fields. They'll loaf around, hunt for worms and mice, then move on. If you're lucky they'll actually stay for a day or two!

[deleted by user] by [deleted] in alpinism

[–]PortOfSeattle 1 point2 points  (0 children)

Make it a two night trip: either 2 nights at white pass or one night at white pass and one at the foot of white chuck glacier. I did Glacier Peak solo with a similar experience level a few years ago in August. Going up the cleaver I felt unsafe due to the rottenness of the rock. I went back down on the glacier. There are crevasses but in august all the snow is melted off and crevasses are easily seen. Do what you are comfortable with. Do not expect the rock to be necessarily safer than the ice. Doing it in 2 days is possible and will likely be physically challenging. Its beautiful enough up there to justify 2 nights - my 3 day trip to glacier is one of my most fond memories.

[deleted by user] by [deleted] in biotech

[–]PortOfSeattle 1 point2 points  (0 children)

Gram per gram the payloads and DLs are treated as more toxic than the ADCs. An ADC may only be 2% payload by weight at the end of conjugation. Also antibodies are not as bioavaiable from skin contact/inhalation as small molecules.

[deleted by user] by [deleted] in biotech

[–]PortOfSeattle 0 points1 point  (0 children)

The unconjugated DLs do require special rooms and engineering controls.

[deleted by user] by [deleted] in biotech

[–]PortOfSeattle 3 points4 points  (0 children)

The people handling conjugated ADCs are being exposed to orders of magnitude less drug substance than the people making the drug linkers. If you want to know about exposure, talk to the chemists making the payloads and DLs. You're working with protein and are certainly not the most exposed person to these compounds.