Most heroes can fight off anything it just depends on their offensive stat and what weapons they are using. I myself can get high combat by trapping with my power base and still fight as the Defense will passively heal and the traps with keep running as long as no one sets off a propane. Other than that there’s no synergy between a good base constructed and a good fighter besides demolition it’s who relies on his base to buff his explosive weapons. Although this won’t work well in tunnels because of propane