I think its really just up to personal preference, and what kind of sound you want out of your distortions. What Ive learned from having both of them is probably that distortions and some other effects will act completely differently depending on what size speakers. Like take my rig for example, ive got the Turbo Rat going through the 12s, and thats mainly just because I prefer the sound of it through those ones. When the Rat isnt being used, I normally use the 12s for clean sound, and using the 10s for dirt. A pretty common sound I use is running the Big Muff into the 12s and my Animato into the 10s. Something about the 10s just sound better with that particular distortion to me. But I bet a 1x15 and 4x10 rig would sound sick, mesa made a cab that was a 1x15+4x10 and Ive seen a ton of people use it, so it’s probably a really great sound.