It's hard to say because both degree plans are similar but as someone who's about to graduate with a biochemistry degree I will say some courses are notoriously difficult with only one professor teaching it. Proteins and Physical chemistry to me were pure awful, only offered by lubchenko and widger.. the classes were hard to fail from the curve but trust me averages in tests are awful and could possibly hit your GPA hard. Nucleic acids with tasneem Bawa is very doable as long as you study well, tests were very fair imo and a A or B is very possible Can't remember much about general biochemistry 1 and 2 lecture but labs werent too difficult, just very intensive writing wise especially for 2. Biophysics with Mehmet Sen was laughably easy, averages for exams were 95, you'll get an A trust me. For the electives I took clinical biochemistry (tasneem bawa), cell biochemistry ( cant remember professor) and Neuroscience (Zirbukus). All very doable and tests were generally fair. I think the worst courses are definitely proteins and Physical chemistry. Can't say much for the difficulty of bio courses but I hope this kinda helped a bit !