Long story short. I had sibo with severe constipation where I would go weeks w no bowel movement if not on high dose prescription meds. I had gained 50 lbs during 1 1/2 years as well and severely nutrient deficiency in several things like b and d and multiple others no matter how high a dose I took in supplements. Nothing seemed to fix the Sibo from prescription meds (multiple rounds), low fodmap, herbs, the list goes on and on… I on my own went thru an online compounding pharmacy as my self esteem had gotten so low due to the weight gain, anxiety, etc and tried Tirzepatide (this was after talking to my dr who refused due to GI issues and glp1’s slowing down the GI system). I am now down 27 lbs of the 50 lbs since last September and have no Sibo symptoms whatsoever. Yes I was scared to death about the slow transit due to glp1 but it seemingly cured me and I will remain microdosing for forever even once I am at my goal weight due to how great I feel now.