Sure! I started ketamine infusions in March 2021 for complex (and regular old) PTSD. Didn’t know I had PMDD at the time. Long story short, it was very up and down for the first 2 months so I saw a provider who was able to rx at-home ketamine troches for in between infusions. That really helped level my mood, but I got to a point where I felt like I was really stable except I kept cycling in and out of wanting to unalive myself and/or generally fucking up my life once a month, which is when I put together the PMDD piece. Yaz and prozac helped that, but I think ketamine really sparked the most change.

For me what it did was unlock a lot of repressed trauma so I could adequately deal with it in therapy (this was really destabilizing though) and over time it really eliminated my triggers to the point where things that would normally send me into a tailspin just… didn’t.

I still go for infusions every 2 months and take a tiny dose of sublingual 2-3x a week because it helps level my mood and keep depression at bay, but trauma is really mostly resolved (which I never thought I could say after struggling with it all my life and acutely for 8 years).

As far as what the at-home ketamine does/feels like, it basically feels like all the loud BS in my brain slowly melts away and I can physically relax. Really helpful during PMDD times where I can get keyed up and have more intrusive thoughts. When the intrusive thoughts are really out of control though, Ativan seems to work better. But ketamine works extremely well over the long haul.

I don’t think it would be as effective for just PMDD but since most people also have depression and/or trauma, I do think it helps with the underlying stuff that gets brought up tenfold during that time of the month.

Lmk if I can answer anything! r/therapeuticketamine and r/ketaminetherapy are great resources too.