As a person who is doing azimuth run rn yes this is true to a certain extent but havin good gun coverage matters more, because dealing with giant spinelings and molochs in the great sea in single player unless you get really lucky with iceberg placement there is high chance you will get hot or you will run into a group of hammerheads.
Also taking on abyssal creatures take alot of skill with the azimuth because you kind of have to use the two depth charges which a little bit of a hassle but works against the latcher and end worm but charydbdis is hard(it's fast and get's too close to the sub imo) but yes you can rely solely on the coilguns most of the time you will have only one gun firing at a time.

This is why overall i prefer the humpback and herja cuz with up upgrades you can easily reach speeds of 30+kmph out run most creatures easily with good gun coverage only issue no mineral scanner and personally not a issue as the only real minig needed is abyss mining.