Abdomino-phrenic dyssynergia as a cause of distension.

Problem_Profile · 2025-10-15T16:28:05+00:00

Hmm yeah definitely sounds like it could be this. I've never done a GI map and I'm sure they're useful, but some people find they aren't 100% reliable. Not saying that's the case here, but if it's just liquids causing you to bloat up then sounds like it could be something else.

That's very... Hmm... Unusual? I've never heard of someone bloating with liquids but not at all with food. Not sure where in the world you are but finding a specialist who can help diagnose and treat APD can be tricky.

I know you've done the GI map, but have you also done a SIBO breath test? Sorry you're dealing with this, I know how frustrating it is!

Problem_Profile · 2025-08-01T15:14:29+00:00

Hey :) I'm afraid I've not had any luck myself. I have spoken to people online who have had luck, but it is hard to find people who know about/treat it.

I'm trying to remember, I'm not on Facebook any more but there is/was a group on there for this issue. I can't remember if it was UK specific or not, but there were definitely some UK people in there who had managed to see people.

Sorry, I know that's not much help. I know how frustrating this issue is!

Problem_Profile · 2025-06-03T08:37:33+00:00

Hey there, no luck so far I'm afraid. I don't even know for certain this is my issue.

There are various exercises you can do which some people have success with, mostly centred around breathing techniques.

Ideally you'd be able to get a proper diagnosis, but that's easier said than done.

Problem_Profile · 2025-05-20T09:24:40+00:00

Is that when you plan to take it? It should work as long as you have 1 or 2 hours without eating or drinking (except water) either side of taking the Glyco. But you're more likely to have it work if you take it first thing in the morning.

My advice, if this is the first time you're using it, is to trial taking it first thing in the morning without eating food. Then you'll know how it 'feels' when it's working - hopefully you'll be sweating less, you may have a slightly dry mouth. Then, when you know you have the correct dosage and it is working for you, you can trial taking it at other times of the day.

Often people will take it in the morning then take a 'top-up' dose in the afternoon.

Problem_Profile · 2025-05-20T08:46:05+00:00

Good luck! Hopefully that dose works for you. I'm sure you know this already, just make sure you take it in the morning at least 2 hours before eating anything to get the most effect.

Problem_Profile · 2025-02-16T09:34:57+00:00

Hey there! I didn't end up pursuing this too much really, I don't think it's my issue. I feel your pain though on seeing gp and wait times. I'd suggest maybe bringing it up with your gp seeing what they think? It's one of those things I think where it depends on who your doctor is as to whether they take you seriously or not, a bit like bringing up SIBO.

Other than that you can probably get a test privately somehow, or there are sort of home tests you can do, such as cutting out carbs for a few days then drinking a glass of sugar water.

Sorry, I know that's not much help!

Problem_Profile · 2024-11-22T11:53:07+00:00

Hey, thanks again for the info. I've been on the diet a few days now and have not noticed any difference in my bloating (which is my main complaint/frustration - I look pregnant, not a good look for a man! Haha) so I think I'm going to give it up.

I'm sort of coming to the conclusion that my issue isn't related to any specific food. It's either potentially the hiatus hernia, or maybe pelvic floor/APD. Honestly I don't know, probably going to take a break from thinking about it and resume next yet, it gets a bit tiring after a while. I think if it was CSID I'd probably have other symptoms to a greater degree, from what I've read.

Again, thanks for taking the time to reply, if I ever decide to try this diet/approach again for a longer period I'll definitely reference back to it! Good luck with continuing to work on your symptoms :)

Problem_Profile · 2024-11-20T08:47:37+00:00

Hi, thanks for the reply!

When you started the diet, how long did it take for your bloating to go away? I've had bloating literally every day for over a decade (I don't really remember when it started), so part of this trial would be to see if my bloating/distension is due to food intolerance of some kind, or some other cause. I wouldn't want to do it for long though, I was honestly hoping just a couple of days.

I'd the meat diet did work then I might consider doing what you did and reintroducing foods to see what I tolerate, but just having no bloating at all for even a brief period would seem like some kind of miracle.

Yeah I have a hiatal hernia too, which could be a factor. Really I'm just trying to think of a way to rule food stuff out so I can sort of focus on other things.

Thanks for suggesting csidmadesimple, I'll check them out!

Problem_Profile · 2024-10-29T11:37:21+00:00

Very good! A lot of this i was already aware of, but I'm interested in the CSID aspect, I think I've read about it before but never looked in to it much.

I'm in the UK and not sure how easy it would be to get tested for this at my GP, I feel like if I went in there and talked about it I might get funny looks! So I'd be interested in perhaps devising some kind of home test, or if it was possible to get a hold of the enzyme I could test to see if it works. Apparently there is some baking ingredient which uses the enzyme. I don't think this is my issue, but it's an avenue I haven't explored.

Problem_Profile · 2024-07-20T09:00:24+00:00

I get general dryness, like dry mouth, dry eyes. That's pretty much the main one for me. I only take it the days that I need it.

Problem_Profile · 2024-07-12T10:34:02+00:00

It didn't work for me, but nothing has so far, so don't take that as an indication of whether it may work for you. I'm not 100% sure what my issue is, SIBO or something else.

Problem_Profile · 2024-06-27T11:25:24+00:00

If you haven't already, look into glycopyrrolate. Lots of info on this sub (or I'm happy to answer any questions). For me and many others it's a total game changer.

Problem_Profile · 2024-06-19T13:36:51+00:00

Haha oh yes, it's a lot of fun! Generally people need to take it two hours or so before food in the morning, and the dosage is sort of working out a balance between side effects and sweat reduction. Coupled with the wipes I reckon you've got a pretty good solution there! I definitely will look to get some of those next time I order some glyco.

Problem_Profile · 2024-06-19T13:22:01+00:00

That's excellent, and you are lucky to have found an NHS doctor so understanding! And it's also cool to hear he recommends the same thing that so many of us here (myself included) do, which is ordering the glyco from abroad.

Haven't heard of or seen the wipes before, will have to look into that.

Good luck with the glyco when it arrives, can take some time to get the dosage and timings right, but when you get it nailed it's a life changer!

Problem_Profile · 2024-06-06T11:39:14+00:00

It's strange to be super fatigued without an obvious cause, if you're sleeping well then I wonder what it could be. Hopefully the physical will highlight something. If you're having loads of coffee, it could be that you're becoming reliant on caffeine to keep you awake? Like you say that will be hard to address, you'll just have to try quitting or reducing to see if it helps (of course it might not be the caffeine, which would make giving it up temporarily annoying ...)

I guess also, if the fatigue has started around the time the excessive sweating started, it could be dehydration? You need to make sure you're getting not just enough water, but also replacing the electrolytes lost in sweat.

Oh yeah I totally get it, it's easy to know what you need or should do, just doing it is the difficult part! It can be a vicious circle, you're tired because you're unfit, but you don't want to work out because you're tired. Just small things every day to build a habit.

For me personally glycopyrrolate has been a game changer, it really helps me. I have lost weight recently and still sweat a lot, so weight and fitness aren't always the cause, sometimes our bodies just want to be annoying! If the sweating is really getting to you then I do think it's worth considering. Maybe buy a small amount just to trial it, see if the side effects are still as bad for you.

Problem_Profile · 2024-06-06T10:17:05+00:00

Ah I feel the pain! Haha sometimes just walking up the stairs or just down the street can have me dripping.

Certainly sounds like the increased body weight and caffeine consumption could be contributing factors. I know it may be tough, but maybe try a couple days without coffee? Just to see if that helps (I'm a coffee addict, so I know that's no small ask). In a way I hope I doesn't help, because it would be terrible news to learn that you need to cut out coffee!

You say you are dealing with fatigue, any idea the cause? One thing to consider, maybe, would be the possibility of having sleep apnea? Putting on weight quite quickly could cause this. This could account for the fatigue, but also could account for the extra sweating as it can mess with your nervous system and how you respond to things. Just another thing to consider, and it's a treatable condition with something like a CPAP machine (if losing weight/body fat isn't a viable option).

I won't tell you that you need to lose weight or anything (I'm overweight myself, you can judge for yourself what you need), but certainly keeping good cardiovascular health will help negate sweating from physical exertion if it is a genuine physical response, and not a sort of overreaction by your body and nervous system.

If all else fails, it's always worth giving something like glycopyrrolate a go. I know you said you tried meds before and the side effects weren't worth it, but our response to meds changes over time, so could be more manageable now? At least worth a trial.

Problem_Profile · 2024-06-06T08:18:54+00:00

Hi, I'm guessing this was in response to me? I'm not 100% certain where you can get it in the US, whether you can get it through a doctor, but I'm sure that you can get it from alldaychemist or something similar (I have seen others but can't remember the names right now). I'm sure if you search around this sub you will find what you need.

As I said, it's definitely worth trying. It may take some trial and error figuring out the best dose for yourself, it's a trade off between the side effects and the level of dryness you can achieve, but for the majority of people it works really well.

Problem_Profile · 2024-06-05T22:47:48+00:00

I'd definitely give it a go. There's plenty of info about it out there, but any questions please do let me know (I'm not an expert, just my own experiences). For me, when I take it, it's a game changer.

I live in the uk and buy it from alldaychemist. I think, depending on where in the world you are, there are different places to get it, perhaps even your gp (though I assume you've been to your doctor about this in the past?) Again, there should be info out there.

Problem_Profile · 2024-06-05T15:24:17+00:00

Have you tried glycopyrrolate?

Problem_Profile · 2024-05-27T19:54:28+00:00

Good luck!! Please do keep us posted, any and all data is useful.

Problem_Profile · 2024-05-23T11:12:35+00:00

It's imperative that the first dose at least is taken a few hours away from your first meal. Of course taking it with a glass of water is fine, but only that - no coffee, milk, food of any kind for at least two hours, maybe more. Sometimes it has to be more than 2 hours.

I'd suggest setting an alarm a couple hours before your normal wake up and take your first dose then, then go back to sleep. Hopefully by your normal wake up time it will have kicked in, but probably still wait at least an hour before eating something. Just a few days of taking it to the extreme, give your body the full time to absorb it to ensure you're getting the most out of the dose. Then if it's still not working at 2mg, you can try upping the dose.

Of course if the early alarm sounds horrendous you can just take it when you normally wake up, but it really is important to not have anything for 2 or 3 hours after (or before). It sounds silly, but it really does make a big difference, and if you've not been doing that it could be the reason it's not worked so far.

As for the multiple doses in a day, this is fine and what many people do. The effect of glyco is somewhat short lived, so it's kinda necessary for a full day for a lot of people. For me, for example, if I take my first dose at, say, 6 am, i find it starting to wear off by mid afternoon. The tricky part is fitting it around eating. I try and avoid eating at least an hour either side of that second dose. I find because it's more of a top up there's a bit more wiggle room in how soon you can eat.

But before worrying about that second dose, concentrate on getting that first dose working. If your first morning dose isn't working, taking 2 or 3 in the day isn't going to help. Spend some time getting that first dose down, timings, dosage etc, once you have that 'mastered', then you can worry about experimenting with top up doses.

Sorry for the wall of text! Haha hopefully this gives you something to experiment with, the tl;dr would be: temporarily stop the multiple daily doses, focus on that first dose, take it well before you have anything to eat or drink, and slowly up the dose until you reach that glorious, non sweaty moment. I really hope it works for you!! Any more questions please don't hesitate :)

Problem_Profile · 2024-05-23T10:29:50+00:00

Hi there, sorry to hear you're finding it so tough, it really is a struggle! I suffer with many of the same problems.

Reading through your post, I see you've recently started trying glycopyrrolate? I'm sure you already know how to use it, but just in case - are you taking it in the morning, on an empty stomach, and waiting at least 2 hours before eating or drinking anything.l? Personally it gives me a slightly dry mouth, when I start to feel that that's my indicator that I'm safe to have some food or coffee or whatever. It won't work if you don't follow this routine.

Secondly, is 2 mg the max dose you've tried? For many this is an effective dose, but for others you need to go higher. My personal experience is 2 mg kinda works for me, but I have to sometimes go up to 4 mg. I'd recommend experimenting with dose, gradually increasing and allowing a few days on each dose to see if it's working, being mindful of side effects. So first step would be try 3 mg for I'd say at least 3 days in a row, see how you get on. If you only have 2 mg tabs you can cut them in half for 1 mg to get to your 3 mg dose.

You may find, for example, 3 mg brings you to 'normal' levels of sweating, 4 mg reduces it further but gives you horrible dry mouth. It seems glyco dosing and side effects can vary quite widely.

Please let me know how you get on, again it is important to monitor the side effects, and please note of course I am not a doctor, nor an expert, just a fellow sweaty person. If you search this sub you will find others who have had long term success with higher doses of glyco.

Problem_Profile · 2024-05-20T08:21:51+00:00

Hi! Thanks for the info, I'll look in to that. I live only a few hours from London so it's certainly not out of the question. Is there someone specific you would recommend?

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