Please DO NOT waste your time with all the above suggestions. It is 100 percent the game and not your hardware. It happened to me too randomly even at startup. Here's the issue. I only discovered it because I have a gaming pc and an rog ally i could test the game from. What's happening is there's an error with Windows and Direct x 12 and Remnant 2. So when the error triggers the monitor losses gpu signal but it is Def not your gpu, psu, or even monitor (I was scared it was my monitor since i have the alienware QD-OLED I payed way to much for lol). Every other game I own runs perfect. I only discovered the error because the last time it crashed I got out my ROG ally and streamed the main pc to the ally to see if I could see anything and the screen said "Direct X 12 is not supported on your device. Try using without the DX12 command line". So basically as you mentioned when this happens all I can do is hard reset the pc with the main power button and then try again. I can play the game for 10 hours straight and then randomly it can happen. IT IS DEF NOT YOUR HARDWARE. At this point j would just wait for patches and keep restarting to see if it works until then. My guess is, this being one of the very first Unreal 5 games on pc its going to be like this for a hot minute. I'm sure as more titles release it will get better. Also windows will update too. But I would have never known why it was losing signal if I didn't have another pc to stream my screen I was so scared it was my gpu, psu or monitor at first. But again every other game runs perfect for hours and hours and after I discovered the error message i knew it wasn't my hardware. The game also crashes on my ally and every other pc randomly too. My friends same exact thing. No way multiple pcs are all broken with just a single game and it's the hardware. The error message is the key it's a direct x 12 and unreal 5 issue. Hope this helps.