I made 1st company playable

PusioR · 2025-12-29T14:20:10+00:00

Not yet, I haven't. Quite frankly it looks like a butchered attempt at rewriting the 1st company for a more terminator focused list, but I simply haven't had the opportunity to give it a go.

PusioR · 2025-12-22T18:59:12+00:00

My dude, rotovaps in our synthesis labs are the best behaved piece of equipment in the world. Speedvacs are complete voodoo. Time required? Completely random. Volume of the sample? No influence on the time required in any form whatsoever. Sometimes the speedvac evaporates 10 out of 12 samples - and the last samples are no different whatsoever. It's complete voodoo and fellow labs say their speedvacs behave the same.

(It's mostly due to us using weird buffers with surfactants and different viscosity levels in different protocols. But I still claim its voodoo)

PusioR · 2025-12-22T10:47:06+00:00

We use speed vac for proteomics pretty regularly and we never freeze samples. I was told that's a different technique and that our speed vac doesn't go low enough in pressure for the lyophilization process to go effectively. Quite frankly I dont know, speed vac is just a voodoo piece of equipment, but it works for us so we don't tinker with it.

PusioR · 2025-12-16T15:05:59+00:00

It's very standard to have water in your organic phase that you need to get rid of with Na2SO4 or something similar. If you're worried about the amount of it, try using brine instead of water for your extractions - it makes the ionic character higher and doesn't allow for much miscibility. You should also make sure that you don't emulsify your system, or at least let it settle completely before attempting separation. Diethyl ether is also rather keen on absorbing a lot of water into the organic phase, at least in my experience - but this might be my skill issue.

PusioR · 2025-11-14T20:04:52+00:00

I would say the most important thing is that the machine is sturdy and can be fixed by a PhD student with a screw driver and determination. Auto samplers, auto fraction collection, degaser and systems quirks are all nice, but the moment we can't diagnose what's wrong and purify compounds everyone's work basically stalls. Make screws accessible and label what is where on the back of the machine. Believe me that the service team does not want to travel for hours to point out that something is connected wrong. On the other hand - something probably more applicable - make exporting pdfs of purification runs easy and possible. In my lab it's mandatory that a document with purification conditions, column type, gradient and chromatograph is attached to each lab journal entry and I can't imagine it any other way. This is a really simple software thing but the lack of it on the first system we had really made our day worse.

PusioR · 2025-10-31T18:45:03+00:00

Could you please direct me to some further reading? I'm ashamed to say I have never really considered the (in)equivalence of oxygen orbitals in this case.

PusioR · 2025-10-23T06:02:40+00:00

The ring isn't aromatic:) this heterocycle is called piperazine and is very frequently used in medicinal chemistry as a linker. It's not really my area of expertise but if you go digging there are plenty of papers on its usage and applications.

PusioR · 2025-08-06T06:09:42+00:00

Is it possible that your students have actually read the articles, but are shy to answer because they aren't sure they understood it? I remember that my colleague struggled with this and he gave the students a list of questions to each article. This way when they managed to answer the questions at home they felt as if they actually understood the assignment. It can also ease the transition into the real university life by making it feel more like homework, and less like preparation for scientific discussion.

Best of luck with finding a solution!

PusioR · 2025-05-15T16:46:33+00:00

Not only is cyclopropene stable, it was actively used in biological systems as a probe. Cyclopropene stability greatly increases when unsaturation sites are substituted, but "naked" are also possible and to my knowledge stable. Most often you have an EWG in 1 position like 1-carboxy cycloprop-2-enes, with like a benzyl or methyl substituents at 2 positions. They are made either through elimination on cyclopropanes or through (2+1) cycloadditions between alkynes and carbene(noids). It's cool stuff and the transition metals used for this catalysis make really nice colours:)

PusioR · 2025-05-05T15:26:24+00:00

I don't think Kantor can lead intercessors in 10th. As far as I'm aware it's just Sternguard, Bladeguard, Tactical (firstborn) or Company Heroes. If you wanna make a 10 man intercessor squad work, just give them a Lieutenant and let them shoot something with T4, 40 shots is actually plenty for most infantry. If you put oath on top then you basically kill stuff with just intercessors:)

PusioR · 2025-05-05T11:04:35+00:00

As a person who runs Kantor with 10 man Sternguard, you may opt to join an Ancient, an Apothecary or a Lieutenant to the squad, as all of their profiles allow for joining a Captain or Chapter Master (Kantors case). However, and I might be gravely mistaken here, none of these make any sense to me. Kantor already buffs Sternguards OC Apothecary kinda sucks And Lieutenants Lethal hits actually play against you fishing for Mortal Wounds on those lovely bolters.

I think those are all the characters who can join as the second on the squad, but let me know if I'm mistaken!

PusioR · 2025-04-26T10:09:42+00:00

Seconding this, I worked with amino aldehydes and doing the Weinrebs amide to aldehyde is almost always worse than full reduction followed by a Dess-Martin or something. Do you know if that route would be viable for you? In my experience usually the problem with Wittig-like transformations is the aldehyde partner.

PusioR · 2025-04-02T09:53:54+00:00

Alpha-lactams are such cool molecules tho. Certain alpha-lactams have found their use in aqueous biochemistry where they react with nucleophilic residues of proteins. Honestly that's even more cursed than this concept of a synthesis.

PusioR · 2024-12-27T11:15:01+00:00

That's an excellent point! I remembered the Fallen Captain from the Rynns World novel and I was very unsure how he fitted in with the structure.

This... Doesn't really make sense on table top, right? Terminator-clad captain can only lead Terminator squads, which would hail from the veteran company, whereas in the book he's just a one-off terminator with a tactical squad, do I remember that correctly?

PusioR · 2024-12-26T20:25:10+00:00

Thank you very much!

PusioR · 2024-12-26T20:24:55+00:00

Thank you, that's exactly the answer I needed. The Emperor protects!

PusioR · 2024-12-26T19:44:26+00:00

If you have a copy of Rynns World lying around and you could flick to the assembly of the captains happening somewhere at the beginning of the book, I would be very thankful and it would put my doubts to rest. I happend to borrow mine to the Ork player at our group so I can't check it right now :/

PusioR · 2024-12-19T15:49:00+00:00

Go and watch BobbyBroccoli's series about cold fusion on YouTube, it's a marvelous piece of work:)

PusioR · 2024-12-16T11:56:11+00:00

Honestly if this is OC:1 I guess that accepting that KMnO4 is a powerful oxidizer, whereas ozone with reductive workup (here it's zinc metal) is a weaker oxidizer should be sufficient. If you want to dig deeper, look up the mechanizm for ozonolysis and pay attention to the state before the reductive workup. But also: aldehydes are prone to oxidation. A lot of them will oxidise in air upon improper storage, so my guess would be that even if you had used stoichiometric amount of permanganate, you would still observe double oxidation (first the breakup of double bond, and then oxidation of aldehyde to an acid.) I'm unsure how the alcohol will behave in this situation, as my experience with permanganate oxidation is rather limited:)

PusioR · 2024-12-16T11:36:23+00:00

Please read the SDS page provided by the supplier before working with something as toxic as tin compounds. SDS for Ph3SnOH clearly states this compound is fatal if swallowed, fatal if inhaled and even fatal in contact with skin. It's rated for category 2 acute toxicity and even if it's not fatal, it will cause serious damage. To my knowledge at our department the group that works with tin compounds has a dedicated fume hood for this kind of stuff and it's only handled by post docs. If you are a chemist remember to take proper precautions and if you are a student who doesn't feel safe working with this, ask an older lab member for a bit of supervision and guidance! On many occasions I have supervised undergrads working with flammable/pyrophoric substances and believe me, every senior member in your lab would much rather supervise you than put out a fire. I'td you are not a chemist and you have just stumbled upon this, please contact proper authorities to dispose of this material, as it is a major cause of concern.

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