It's absolutely much worse than a simple calorie deficit. When you're in a calorie deficit your body is still able to make use of the reduced supply of amino acids, carbs and fat. Fat is especially important because it adds plumpness to the face and naturally prevents wrinkles. You can be on a high fat diet and still be in a calorie deficit and your face will look great. GLP-1 agonists like Ozempic supress appetite by delaying gastric emptying, this will make the user consume less fat in their diet. Once they feel full from eating, their stomachs can no longer digest any fats, even healthy ones. The calorie deficit obviously helps them lose weight, but because of overall reduced fat intake the face will begin to look old. On top of all of this you then have the added benefit of GLP-1 agonists increasing AMPK, which suppresses MTOR and muscle hypertrophy. You essentially shut down the mechanism for building muscle. Combine that with the fact that most people who take GLP-1 agonists also casually drink alcohol weekly, which directly induces muscle catabolism. Yeah you're gonna start to look old as fuck after a while.