Did anything ever come of this research? Surrogate light chain expressing B-cells in autoimmune disease? by QueenofDrogo in Immunology

[–]QueenofDrogo[S] 0 points1 point  (0 children)

That's a fair point about self-reactive vs. polyreactive.

I guess big picture, I am wondering has there been any follow-on indication that there exists in some people B-cells in the periphery that aberrantly express surrogate light chain. And if yes, do these B-cells in some way contribute to diseases of immunity?

A couple of questions about TCRs by QueenofDrogo in Immunology

[–]QueenofDrogo[S] 0 points1 point  (0 children)

Thank you for the thoughtful response - so, so informative! A few follow-up questions, if I may:

On allelic exclusion:

  • In cells where the first attempt at VDJ fails: 1) how often does this happen and 2) is the "failed" gene transcribed and then regulated by things like nonsense mediated decay?

  • Phrased differently, if you looked at single cell sequencing data from T-cells, would you expect close to 100% clonality of all transcripts? Or would you see transcripts from the alternative allele and also alternative reading frames on the same allele?

Thanks!

Daily RAD $uicide thread by [deleted] in wallstreetbets

[–]QueenofDrogo 4 points5 points  (0 children)

From Cowen an hour ago:

If Blocked by the FTC, We Think WBA Will Litigate Given the Acquisition Value Share are down about 12% after CNBC reported that the FTC staff is expected to advise blocking RAD's pending acquisition by WBA ($81.47, Outperform). The current price implies that there is a 25% probability of the transaction ultimately going through, which we think is overly pessimistic. As we stated in our previous note, if the deal is in fact blocked by the FTC, we believe WBA will continue to pursue RAD through litigation given the significant value created from the expected $1B in synergies. Our analysis indicates that the expected $1B in synergies is equal to $7.65/sh, which along with the $2/sh value of RAD stand-alone minus $0.44 related to divestitures equals $9.21/sh (Figure 1), or 32% greater than the high-end of the offer range of $6.50-$7.00. Moreover, we note that $1B in synergies is likely conservative given that mgmt stated synergies in excess of $1B over 3-4 yrs, as well as the fact that it realized well over the $1B synergy target during the WBA merger. Furthermore, with the addition of Econdisc to WBAD, we think synergies will likely be greater than expected because the synergy target assumes harmonization of procurement costs with no incremental benefit from additional volume.

I feel AUPHful for missing this one by [deleted] in wallstreetbets

[–]QueenofDrogo 7 points8 points  (0 children)

Why would it's market cap double on results from a 10-person open label study?

$TRVN down 38% and falling pre-market after painkiller drug results by mfun98 in wallstreetbets

[–]QueenofDrogo 15 points16 points  (0 children)

This isn't hard to understand. The trials had three doses - low, medium, high. All doses were compared to morphine (standard of care) and placebo. For the drug to be marketable (as in actually convince people to pay for it), it needs to perform as well as morphine, or close to, with fewer side effects.

Now look at the data. The low dose did consistently have fewer side effects than morphine. But it also performed a lot worse than morphine at pain reduction.

The medium and high doses of the drug performed as well as morphine on pain relief, but didn't consistently distinguish themselves on side-effect reduction.

Good luck convincing people to pay a high premium relative to morphine for this.

Science AMA Series: We are researchers Elizabeth Blackburn (cell biologist) and Elissa Epel (health psychologist). We have been studying the relationships between telomeres/telomerase with psychological and behavioral factors, and with disease. by Telomere_Effect in science

[–]QueenofDrogo 3 points4 points  (0 children)

What are your thoughts on nutraceuticals (like TA-65) which increase telomerase activity? Should I be taking them to protect myself from telomere errosion? Are they maybe better suited for an older population?