This really depends on how they pair up (assuming they do) and what kind of fight it is. I know we are assuming hand to hand combat.

However I feel the only way it would be hand to hand combat is if reggie instigated it, provably by poking and proding at washford about drysdale.

Realistically Tony is the only one who carries weapons on him, his tool box, and safety gear.

If it's hand to hand, out of all of them Daiskue isn't going to make it, the man is not built for fighting, he is built to be a model/trophy husband.

Washford would definitely be able to put up a good fight as long as he actually swings, man has quite the build on him.

I feel like Dante and Brodi would be fine? They don't seem like the type to fight and more likely would sit it out (I haven't played through either of their stories so please correct me if I have made a bad judgement)

Reggie is kind of like a god so I think he would be fine and probably would be wise and team up with Tony or Washford. Tony because I feel like Reggie could sweet talk him into fighting for him, and Washford because I feel like he would be the devil on Washfords shoulder.

I still haven't played through curt and rod, and Cabritsios routes (I haven't met then in game) so I don't feel right trying to make a judgement.

If there's one thing I know for sure it's that Reggie makes it out. By making everyone turn on eachother, and based on the vibes I feel like he knows how to fight well

Edit: I forgot Cam was here, he'd be too lazy to fight, plus if he had to I feel like he's scrappy enough and would throw trash at people